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Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine

Background: The variation in the reported vaccine safety and effectiveness could contribute to the high rates of vaccine hesitancy among the general population and healthcare workers in areas where monkeypox (mpox) is circulating. In this review, our objective was to evaluate the safety, immunogenic...

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Autores principales: Ghazy, Ramy Mohamed, Elrewany, Ehab, Gebreal, Assem, ElMakhzangy, Rony, Fadl, Noha, Elbanna, Eman Hassan, Tolba, Mahmoud M., Hammad, Elsayed Mohamed, Youssef, Naglaa, Abosheaishaa, Hazem, Hamouda, Elsayed Eldeeb Mehana, Mehana, Zeyad Elsayed Eldeeb, Al Zomia, Ahmed Saad, A Alnami, Raad Ahmed, Salma, Emad Ali Saeed, Alqahtani, Abdulaziz Saleh, Alshehri, Abdulaziz Fayez, Hussein, Mai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674429/
https://www.ncbi.nlm.nih.gov/pubmed/38006040
http://dx.doi.org/10.3390/vaccines11111708
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author Ghazy, Ramy Mohamed
Elrewany, Ehab
Gebreal, Assem
ElMakhzangy, Rony
Fadl, Noha
Elbanna, Eman Hassan
Tolba, Mahmoud M.
Hammad, Elsayed Mohamed
Youssef, Naglaa
Abosheaishaa, Hazem
Hamouda, Elsayed Eldeeb Mehana
Mehana, Zeyad Elsayed Eldeeb
Al Zomia, Ahmed Saad
A Alnami, Raad Ahmed
Salma, Emad Ali Saeed
Alqahtani, Abdulaziz Saleh
Alshehri, Abdulaziz Fayez
Hussein, Mai
author_facet Ghazy, Ramy Mohamed
Elrewany, Ehab
Gebreal, Assem
ElMakhzangy, Rony
Fadl, Noha
Elbanna, Eman Hassan
Tolba, Mahmoud M.
Hammad, Elsayed Mohamed
Youssef, Naglaa
Abosheaishaa, Hazem
Hamouda, Elsayed Eldeeb Mehana
Mehana, Zeyad Elsayed Eldeeb
Al Zomia, Ahmed Saad
A Alnami, Raad Ahmed
Salma, Emad Ali Saeed
Alqahtani, Abdulaziz Saleh
Alshehri, Abdulaziz Fayez
Hussein, Mai
author_sort Ghazy, Ramy Mohamed
collection PubMed
description Background: The variation in the reported vaccine safety and effectiveness could contribute to the high rates of vaccine hesitancy among the general population and healthcare workers in areas where monkeypox (mpox) is circulating. In this review, our objective was to evaluate the safety, immunogenicity, effectiveness, and efficacy of the mpox vaccines. Methods: An extensive search for articles across multiple databases was performed, including searching six databases (PubMed Central, PubMed Medline, Scopus, Web of Science, Cochrane, ProQuest), two pre-print databases (European PMC Preprint and MedRxiv), and Google Scholar. Results: A total of 4290 citations were retrieved from the included databases. Following the removal of duplicates and the initial screening of records, a total of 36 studies were included into the analysis. Additionally, we identified five more studies through manual searches, resulting in a total of 41 eligible articles for qualitative synthesis. The study findings revealed that mpox vaccines demonstrate the ability to generate adequate antibodies; however, their effectiveness may decrease over time, exhibiting varying safety profiles. Most of the included studies consistently reported substantial levels of effectiveness and efficacy against mpox. Interestingly, the number of vaccine doses administered was found to influence the degree of immunogenicity, subsequently impacting the overall effectiveness and efficacy of the vaccines. Furthermore, we found that smallpox vaccines exhibited a form of cross-protection against mpox. Conclusions: Vaccines can be used to prevent mpox and effectively control its spread.
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spelling pubmed-106744292023-11-10 Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine Ghazy, Ramy Mohamed Elrewany, Ehab Gebreal, Assem ElMakhzangy, Rony Fadl, Noha Elbanna, Eman Hassan Tolba, Mahmoud M. Hammad, Elsayed Mohamed Youssef, Naglaa Abosheaishaa, Hazem Hamouda, Elsayed Eldeeb Mehana Mehana, Zeyad Elsayed Eldeeb Al Zomia, Ahmed Saad A Alnami, Raad Ahmed Salma, Emad Ali Saeed Alqahtani, Abdulaziz Saleh Alshehri, Abdulaziz Fayez Hussein, Mai Vaccines (Basel) Review Background: The variation in the reported vaccine safety and effectiveness could contribute to the high rates of vaccine hesitancy among the general population and healthcare workers in areas where monkeypox (mpox) is circulating. In this review, our objective was to evaluate the safety, immunogenicity, effectiveness, and efficacy of the mpox vaccines. Methods: An extensive search for articles across multiple databases was performed, including searching six databases (PubMed Central, PubMed Medline, Scopus, Web of Science, Cochrane, ProQuest), two pre-print databases (European PMC Preprint and MedRxiv), and Google Scholar. Results: A total of 4290 citations were retrieved from the included databases. Following the removal of duplicates and the initial screening of records, a total of 36 studies were included into the analysis. Additionally, we identified five more studies through manual searches, resulting in a total of 41 eligible articles for qualitative synthesis. The study findings revealed that mpox vaccines demonstrate the ability to generate adequate antibodies; however, their effectiveness may decrease over time, exhibiting varying safety profiles. Most of the included studies consistently reported substantial levels of effectiveness and efficacy against mpox. Interestingly, the number of vaccine doses administered was found to influence the degree of immunogenicity, subsequently impacting the overall effectiveness and efficacy of the vaccines. Furthermore, we found that smallpox vaccines exhibited a form of cross-protection against mpox. Conclusions: Vaccines can be used to prevent mpox and effectively control its spread. MDPI 2023-11-10 /pmc/articles/PMC10674429/ /pubmed/38006040 http://dx.doi.org/10.3390/vaccines11111708 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghazy, Ramy Mohamed
Elrewany, Ehab
Gebreal, Assem
ElMakhzangy, Rony
Fadl, Noha
Elbanna, Eman Hassan
Tolba, Mahmoud M.
Hammad, Elsayed Mohamed
Youssef, Naglaa
Abosheaishaa, Hazem
Hamouda, Elsayed Eldeeb Mehana
Mehana, Zeyad Elsayed Eldeeb
Al Zomia, Ahmed Saad
A Alnami, Raad Ahmed
Salma, Emad Ali Saeed
Alqahtani, Abdulaziz Saleh
Alshehri, Abdulaziz Fayez
Hussein, Mai
Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine
title Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine
title_full Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine
title_fullStr Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine
title_full_unstemmed Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine
title_short Systematic Review on the Efficacy, Effectiveness, Safety, and Immunogenicity of Monkeypox Vaccine
title_sort systematic review on the efficacy, effectiveness, safety, and immunogenicity of monkeypox vaccine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674429/
https://www.ncbi.nlm.nih.gov/pubmed/38006040
http://dx.doi.org/10.3390/vaccines11111708
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