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Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience
HCV infection is still a major burden worldwide, and most countries are not on track to meet the WHO 2030 elimination goal. The current challenge is to identify individuals to be treated. In this study, we will describe the trend of new DAA prescriptions and the changes over time in terms of the cha...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674437/ https://www.ncbi.nlm.nih.gov/pubmed/38005877 http://dx.doi.org/10.3390/v15112199 |
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author | Torre, Pietro Coppola, Roberta Masarone, Mario Persico, Marcello |
author_facet | Torre, Pietro Coppola, Roberta Masarone, Mario Persico, Marcello |
author_sort | Torre, Pietro |
collection | PubMed |
description | HCV infection is still a major burden worldwide, and most countries are not on track to meet the WHO 2030 elimination goal. The current challenge is to identify individuals to be treated. In this study, we will describe the trend of new DAA prescriptions and the changes over time in terms of the characteristics of patients starting antiviral therapy in our unit. Data of 1646 hepatitis C patients who started therapy during the period of 2015–2022 regarding annual number of prescriptions, age, gender, nationality, HCV genotype, provenance, and liver disease severity were analyzed. We observed a peak in the number of new prescriptions in 2018 and a downward trend starting in 2019. Patients from the general population, centers for addictions, and prison differed significantly. The mean age in the general population remained above 60 years, the percentage of patients from centers for addictions and prison increased and, after 2016, there was no significant change in the percentage of patients with F3–F4 fibrosis. As HCV screening and linkage-to-care pathways seem to be already well implemented and successful in centers for addictions and in prisons, efforts need to be focused on those of older age in the general population. To carry this out, the more structured involvement of different health professionals must be figured out. |
format | Online Article Text |
id | pubmed-10674437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106744372023-10-31 Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience Torre, Pietro Coppola, Roberta Masarone, Mario Persico, Marcello Viruses Communication HCV infection is still a major burden worldwide, and most countries are not on track to meet the WHO 2030 elimination goal. The current challenge is to identify individuals to be treated. In this study, we will describe the trend of new DAA prescriptions and the changes over time in terms of the characteristics of patients starting antiviral therapy in our unit. Data of 1646 hepatitis C patients who started therapy during the period of 2015–2022 regarding annual number of prescriptions, age, gender, nationality, HCV genotype, provenance, and liver disease severity were analyzed. We observed a peak in the number of new prescriptions in 2018 and a downward trend starting in 2019. Patients from the general population, centers for addictions, and prison differed significantly. The mean age in the general population remained above 60 years, the percentage of patients from centers for addictions and prison increased and, after 2016, there was no significant change in the percentage of patients with F3–F4 fibrosis. As HCV screening and linkage-to-care pathways seem to be already well implemented and successful in centers for addictions and in prisons, efforts need to be focused on those of older age in the general population. To carry this out, the more structured involvement of different health professionals must be figured out. MDPI 2023-10-31 /pmc/articles/PMC10674437/ /pubmed/38005877 http://dx.doi.org/10.3390/v15112199 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Torre, Pietro Coppola, Roberta Masarone, Mario Persico, Marcello Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience |
title | Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience |
title_full | Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience |
title_fullStr | Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience |
title_full_unstemmed | Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience |
title_short | Country-Wide HCV Elimination Strategies Need to Reach Older Patients in the General Population: The Italian Experience |
title_sort | country-wide hcv elimination strategies need to reach older patients in the general population: the italian experience |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674437/ https://www.ncbi.nlm.nih.gov/pubmed/38005877 http://dx.doi.org/10.3390/v15112199 |
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