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Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery

The work demonstrated the use of natural rubber for topical drug delivery. The first objective was to fabricate a porous deproteinized natural rubber film loaded with silver nanoparticles. Characterizing and assessing its formulation was the second objective. Surface pH, mechanical properties, swell...

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Detalles Bibliográficos
Autores principales: Pichayakorn, Wiwat, Maneewattanapinyo, Pattwat, Monton, Chaowalit, Dangmanee, Nattakan, Suksaeree, Jirapornchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674566/
https://www.ncbi.nlm.nih.gov/pubmed/38004581
http://dx.doi.org/10.3390/pharmaceutics15112603
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author Pichayakorn, Wiwat
Maneewattanapinyo, Pattwat
Monton, Chaowalit
Dangmanee, Nattakan
Suksaeree, Jirapornchai
author_facet Pichayakorn, Wiwat
Maneewattanapinyo, Pattwat
Monton, Chaowalit
Dangmanee, Nattakan
Suksaeree, Jirapornchai
author_sort Pichayakorn, Wiwat
collection PubMed
description The work demonstrated the use of natural rubber for topical drug delivery. The first objective was to fabricate a porous deproteinized natural rubber film loaded with silver nanoparticles. Characterizing and assessing its formulation was the second objective. Surface pH, mechanical properties, swelling ratio, erosion, moisture vapor transmission rate, scanning electron microscopy/energy dispersive X-ray analysis, and X-ray diffraction were evaluated. In vitro studies and antibacterial activity were assessed. It was discovered that silver nanoparticles could enter the film and that their concentrations ranged between 7.25 and 21.03 µg/cm(2). The pH of the film’s surface was 7.00. The mechanical properties of the film with silver nanoparticle loading differed from the blank film. After adding silver nanoparticles, the film eroded faster than before, but the swelling ratio was not affected significantly. Increased time utilization had an impact on the moisture vapor transmission rate of the film. Silver nanoparticles released easily from the film while there was less permeability. The dead pig-ear skin had significant silver nanoparticle accumulation. Potent antibacterial activity was seen in the film containing silver nanoparticles. The silver nanoparticle-loaded film may be used as a wound dressing for a topical film that promotes wound healing while also protecting the area from infection.
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spelling pubmed-106745662023-11-08 Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery Pichayakorn, Wiwat Maneewattanapinyo, Pattwat Monton, Chaowalit Dangmanee, Nattakan Suksaeree, Jirapornchai Pharmaceutics Article The work demonstrated the use of natural rubber for topical drug delivery. The first objective was to fabricate a porous deproteinized natural rubber film loaded with silver nanoparticles. Characterizing and assessing its formulation was the second objective. Surface pH, mechanical properties, swelling ratio, erosion, moisture vapor transmission rate, scanning electron microscopy/energy dispersive X-ray analysis, and X-ray diffraction were evaluated. In vitro studies and antibacterial activity were assessed. It was discovered that silver nanoparticles could enter the film and that their concentrations ranged between 7.25 and 21.03 µg/cm(2). The pH of the film’s surface was 7.00. The mechanical properties of the film with silver nanoparticle loading differed from the blank film. After adding silver nanoparticles, the film eroded faster than before, but the swelling ratio was not affected significantly. Increased time utilization had an impact on the moisture vapor transmission rate of the film. Silver nanoparticles released easily from the film while there was less permeability. The dead pig-ear skin had significant silver nanoparticle accumulation. Potent antibacterial activity was seen in the film containing silver nanoparticles. The silver nanoparticle-loaded film may be used as a wound dressing for a topical film that promotes wound healing while also protecting the area from infection. MDPI 2023-11-08 /pmc/articles/PMC10674566/ /pubmed/38004581 http://dx.doi.org/10.3390/pharmaceutics15112603 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pichayakorn, Wiwat
Maneewattanapinyo, Pattwat
Monton, Chaowalit
Dangmanee, Nattakan
Suksaeree, Jirapornchai
Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
title Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
title_full Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
title_fullStr Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
title_full_unstemmed Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
title_short Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
title_sort porous deproteinized natural rubber film loaded with silver nanoparticles for topical drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674566/
https://www.ncbi.nlm.nih.gov/pubmed/38004581
http://dx.doi.org/10.3390/pharmaceutics15112603
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