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Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674581/ https://www.ncbi.nlm.nih.gov/pubmed/38004379 http://dx.doi.org/10.3390/ph16111515 |
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author | Alfaro, Ignacio Vega, Margarita Romero, Carmen Garrido, Maritza P. |
author_facet | Alfaro, Ignacio Vega, Margarita Romero, Carmen Garrido, Maritza P. |
author_sort | Alfaro, Ignacio |
collection | PubMed |
description | Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis and progression of OC. Old drugs with antitumoral properties have also been studied in the context of cancer, although their antitumor mechanisms are not fully clear. For instance, the antidiabetic drug metformin has shown pleiotropic effects in several in vitro models of cancer, including OC. Interestingly, metformin has been reported to regulate ncRNAs, which could explain its diverse effects on tumor cells. In this review, we discuss the mechanism of epigenetic regulation described for metformin, with a focus on the evidence of metformin-dependent microRNA (miRNAs) and long non-coding RNA (lncRNAs) regulation in OC. |
format | Online Article Text |
id | pubmed-10674581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106745812023-10-24 Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer Alfaro, Ignacio Vega, Margarita Romero, Carmen Garrido, Maritza P. Pharmaceuticals (Basel) Review Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis and progression of OC. Old drugs with antitumoral properties have also been studied in the context of cancer, although their antitumor mechanisms are not fully clear. For instance, the antidiabetic drug metformin has shown pleiotropic effects in several in vitro models of cancer, including OC. Interestingly, metformin has been reported to regulate ncRNAs, which could explain its diverse effects on tumor cells. In this review, we discuss the mechanism of epigenetic regulation described for metformin, with a focus on the evidence of metformin-dependent microRNA (miRNAs) and long non-coding RNA (lncRNAs) regulation in OC. MDPI 2023-10-24 /pmc/articles/PMC10674581/ /pubmed/38004379 http://dx.doi.org/10.3390/ph16111515 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alfaro, Ignacio Vega, Margarita Romero, Carmen Garrido, Maritza P. Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
title | Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
title_full | Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
title_fullStr | Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
title_full_unstemmed | Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
title_short | Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
title_sort | mechanisms of regulation of the expression of mirnas and lncrnas by metformin in ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674581/ https://www.ncbi.nlm.nih.gov/pubmed/38004379 http://dx.doi.org/10.3390/ph16111515 |
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