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Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer

Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis...

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Autores principales: Alfaro, Ignacio, Vega, Margarita, Romero, Carmen, Garrido, Maritza P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674581/
https://www.ncbi.nlm.nih.gov/pubmed/38004379
http://dx.doi.org/10.3390/ph16111515
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author Alfaro, Ignacio
Vega, Margarita
Romero, Carmen
Garrido, Maritza P.
author_facet Alfaro, Ignacio
Vega, Margarita
Romero, Carmen
Garrido, Maritza P.
author_sort Alfaro, Ignacio
collection PubMed
description Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis and progression of OC. Old drugs with antitumoral properties have also been studied in the context of cancer, although their antitumor mechanisms are not fully clear. For instance, the antidiabetic drug metformin has shown pleiotropic effects in several in vitro models of cancer, including OC. Interestingly, metformin has been reported to regulate ncRNAs, which could explain its diverse effects on tumor cells. In this review, we discuss the mechanism of epigenetic regulation described for metformin, with a focus on the evidence of metformin-dependent microRNA (miRNAs) and long non-coding RNA (lncRNAs) regulation in OC.
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spelling pubmed-106745812023-10-24 Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer Alfaro, Ignacio Vega, Margarita Romero, Carmen Garrido, Maritza P. Pharmaceuticals (Basel) Review Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis and progression of OC. Old drugs with antitumoral properties have also been studied in the context of cancer, although their antitumor mechanisms are not fully clear. For instance, the antidiabetic drug metformin has shown pleiotropic effects in several in vitro models of cancer, including OC. Interestingly, metformin has been reported to regulate ncRNAs, which could explain its diverse effects on tumor cells. In this review, we discuss the mechanism of epigenetic regulation described for metformin, with a focus on the evidence of metformin-dependent microRNA (miRNAs) and long non-coding RNA (lncRNAs) regulation in OC. MDPI 2023-10-24 /pmc/articles/PMC10674581/ /pubmed/38004379 http://dx.doi.org/10.3390/ph16111515 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alfaro, Ignacio
Vega, Margarita
Romero, Carmen
Garrido, Maritza P.
Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
title Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
title_full Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
title_fullStr Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
title_full_unstemmed Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
title_short Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer
title_sort mechanisms of regulation of the expression of mirnas and lncrnas by metformin in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674581/
https://www.ncbi.nlm.nih.gov/pubmed/38004379
http://dx.doi.org/10.3390/ph16111515
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