Long Non-Coding RNA as a Potential Biomarker for Canine Tumors

SIMPLE SUMMARY: Cancer is the leading cause of death in dogs. Currently, researchers find long non-coding RNA (lncRNA) is a crucial regulator in the progression of various types of cancers. This article emphasizes the current and future advancements in lncRNAs as potential biomarkers for diagnosing, monitoring, and treating different types of canine tumors, which will benefit veterinary medicine as well as comparative medicine. ABSTRACT: Cancer is the leading cause of death in both humans and companion animals. Long non-coding RNA (lncRNA) plays a crucial role in the progression of various types of cancers in humans, involving tumor proliferation, metastasis, angiogenesis, and signaling pathways, and acts as a potential biomarker for diagnosis and targeted treatment. However, research on lncRNAs related to canine tumors is in an early stage. Dogs have long been considered a promising natural model for human disease. This article summarizes the molecular function of lncRNAs as novel biomarkers in various types of canine tumors, providing new insights into canine tumor diagnosis and treatment. Further research on the function and mechanism of lncRNAs is needed, which will benefit both human and veterinary medicine.