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Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674619/ https://www.ncbi.nlm.nih.gov/pubmed/38005912 http://dx.doi.org/10.3390/v15112235 |
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author | Moens, Ugo Passerini, Sara Falquet, Mar Sveinbjørnsson, Baldur Pietropaolo, Valeria |
author_facet | Moens, Ugo Passerini, Sara Falquet, Mar Sveinbjørnsson, Baldur Pietropaolo, Valeria |
author_sort | Moens, Ugo |
collection | PubMed |
description | Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in the life cycle of a virus. In this review, we highlight biological implications of the phosphorylation of the monkey polyomavirus SV40 large T and small t antigens, summarize our current knowledge of the phosphorylation of these proteins of human polyomaviruses, and conclude with gaps in the knowledge and a proposal for future research directions. |
format | Online Article Text |
id | pubmed-10674619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106746192023-11-09 Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field Moens, Ugo Passerini, Sara Falquet, Mar Sveinbjørnsson, Baldur Pietropaolo, Valeria Viruses Review Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in the life cycle of a virus. In this review, we highlight biological implications of the phosphorylation of the monkey polyomavirus SV40 large T and small t antigens, summarize our current knowledge of the phosphorylation of these proteins of human polyomaviruses, and conclude with gaps in the knowledge and a proposal for future research directions. MDPI 2023-11-09 /pmc/articles/PMC10674619/ /pubmed/38005912 http://dx.doi.org/10.3390/v15112235 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moens, Ugo Passerini, Sara Falquet, Mar Sveinbjørnsson, Baldur Pietropaolo, Valeria Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field |
title | Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field |
title_full | Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field |
title_fullStr | Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field |
title_full_unstemmed | Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field |
title_short | Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field |
title_sort | phosphorylation of human polyomavirus large and small t antigens: an ignored research field |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674619/ https://www.ncbi.nlm.nih.gov/pubmed/38005912 http://dx.doi.org/10.3390/v15112235 |
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