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Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field

Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability...

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Autores principales: Moens, Ugo, Passerini, Sara, Falquet, Mar, Sveinbjørnsson, Baldur, Pietropaolo, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674619/
https://www.ncbi.nlm.nih.gov/pubmed/38005912
http://dx.doi.org/10.3390/v15112235
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author Moens, Ugo
Passerini, Sara
Falquet, Mar
Sveinbjørnsson, Baldur
Pietropaolo, Valeria
author_facet Moens, Ugo
Passerini, Sara
Falquet, Mar
Sveinbjørnsson, Baldur
Pietropaolo, Valeria
author_sort Moens, Ugo
collection PubMed
description Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in the life cycle of a virus. In this review, we highlight biological implications of the phosphorylation of the monkey polyomavirus SV40 large T and small t antigens, summarize our current knowledge of the phosphorylation of these proteins of human polyomaviruses, and conclude with gaps in the knowledge and a proposal for future research directions.
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spelling pubmed-106746192023-11-09 Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field Moens, Ugo Passerini, Sara Falquet, Mar Sveinbjørnsson, Baldur Pietropaolo, Valeria Viruses Review Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in the life cycle of a virus. In this review, we highlight biological implications of the phosphorylation of the monkey polyomavirus SV40 large T and small t antigens, summarize our current knowledge of the phosphorylation of these proteins of human polyomaviruses, and conclude with gaps in the knowledge and a proposal for future research directions. MDPI 2023-11-09 /pmc/articles/PMC10674619/ /pubmed/38005912 http://dx.doi.org/10.3390/v15112235 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moens, Ugo
Passerini, Sara
Falquet, Mar
Sveinbjørnsson, Baldur
Pietropaolo, Valeria
Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
title Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
title_full Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
title_fullStr Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
title_full_unstemmed Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
title_short Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
title_sort phosphorylation of human polyomavirus large and small t antigens: an ignored research field
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674619/
https://www.ncbi.nlm.nih.gov/pubmed/38005912
http://dx.doi.org/10.3390/v15112235
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