Cargando…

Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, most known as ulcerative colitis (UC) and Crohn’s disease (CD), that affects the gastrointestinal tract (GIT), causing considerable symptoms to millions of people around the world. Conventional therapeutic strategies have limitatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopes, Sílvio André, Roque-Borda, Cesar Augusto, Duarte, Jonatas Lobato, Di Filippo, Leonardo Delello, Borges Cardoso, Vinícius Martinho, Pavan, Fernando Rogério, Chorilli, Marlus, Meneguin, Andréia Bagliotti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674632/
https://www.ncbi.nlm.nih.gov/pubmed/38004578
http://dx.doi.org/10.3390/pharmaceutics15112600
_version_ 1785140873937289216
author Lopes, Sílvio André
Roque-Borda, Cesar Augusto
Duarte, Jonatas Lobato
Di Filippo, Leonardo Delello
Borges Cardoso, Vinícius Martinho
Pavan, Fernando Rogério
Chorilli, Marlus
Meneguin, Andréia Bagliotti
author_facet Lopes, Sílvio André
Roque-Borda, Cesar Augusto
Duarte, Jonatas Lobato
Di Filippo, Leonardo Delello
Borges Cardoso, Vinícius Martinho
Pavan, Fernando Rogério
Chorilli, Marlus
Meneguin, Andréia Bagliotti
author_sort Lopes, Sílvio André
collection PubMed
description Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, most known as ulcerative colitis (UC) and Crohn’s disease (CD), that affects the gastrointestinal tract (GIT), causing considerable symptoms to millions of people around the world. Conventional therapeutic strategies have limitations and side effects, prompting the exploration of innovative approaches. Probiotics, known for their potential to restore gut homeostasis, have emerged as promising candidates for IBD management. Probiotics have been shown to minimize disease symptoms, particularly in patients affected by UC, opening important opportunities to better treat this disease. However, they exhibit limitations in terms of stability and targeted delivery. As several studies demonstrate, the encapsulation of the probiotics, as well as the synthetic drug, into micro- and nanoparticles of organic materials offers great potential to solve this problem. They resist the harsh conditions of the upper GIT portions and, thus, protect the probiotic and drug inside, allowing for the delivery of adequate amounts directly into the colon. An overview of UC and CD, the benefits of the use of probiotics, and the potential of micro- and nanoencapsulation technologies to improve IBD treatment are presented. This review sheds light on the remarkable potential of nano- and microparticles loaded with probiotics as a novel and efficient strategy for managing IBD. Nonetheless, further investigations and clinical trials are warranted to validate their long-term safety and efficacy, paving the way for a new era in IBD therapeutics.
format Online
Article
Text
id pubmed-10674632
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106746322023-11-08 Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview Lopes, Sílvio André Roque-Borda, Cesar Augusto Duarte, Jonatas Lobato Di Filippo, Leonardo Delello Borges Cardoso, Vinícius Martinho Pavan, Fernando Rogério Chorilli, Marlus Meneguin, Andréia Bagliotti Pharmaceutics Review Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, most known as ulcerative colitis (UC) and Crohn’s disease (CD), that affects the gastrointestinal tract (GIT), causing considerable symptoms to millions of people around the world. Conventional therapeutic strategies have limitations and side effects, prompting the exploration of innovative approaches. Probiotics, known for their potential to restore gut homeostasis, have emerged as promising candidates for IBD management. Probiotics have been shown to minimize disease symptoms, particularly in patients affected by UC, opening important opportunities to better treat this disease. However, they exhibit limitations in terms of stability and targeted delivery. As several studies demonstrate, the encapsulation of the probiotics, as well as the synthetic drug, into micro- and nanoparticles of organic materials offers great potential to solve this problem. They resist the harsh conditions of the upper GIT portions and, thus, protect the probiotic and drug inside, allowing for the delivery of adequate amounts directly into the colon. An overview of UC and CD, the benefits of the use of probiotics, and the potential of micro- and nanoencapsulation technologies to improve IBD treatment are presented. This review sheds light on the remarkable potential of nano- and microparticles loaded with probiotics as a novel and efficient strategy for managing IBD. Nonetheless, further investigations and clinical trials are warranted to validate their long-term safety and efficacy, paving the way for a new era in IBD therapeutics. MDPI 2023-11-08 /pmc/articles/PMC10674632/ /pubmed/38004578 http://dx.doi.org/10.3390/pharmaceutics15112600 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lopes, Sílvio André
Roque-Borda, Cesar Augusto
Duarte, Jonatas Lobato
Di Filippo, Leonardo Delello
Borges Cardoso, Vinícius Martinho
Pavan, Fernando Rogério
Chorilli, Marlus
Meneguin, Andréia Bagliotti
Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
title Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
title_full Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
title_fullStr Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
title_full_unstemmed Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
title_short Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
title_sort delivery strategies of probiotics from nano- and microparticles: trends in the treatment of inflammatory bowel disease—an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674632/
https://www.ncbi.nlm.nih.gov/pubmed/38004578
http://dx.doi.org/10.3390/pharmaceutics15112600
work_keys_str_mv AT lopessilvioandre deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT roquebordacesaraugusto deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT duartejonataslobato deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT difilippoleonardodelello deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT borgescardosoviniciusmartinho deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT pavanfernandorogerio deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT chorillimarlus deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview
AT meneguinandreiabagliotti deliverystrategiesofprobioticsfromnanoandmicroparticlestrendsinthetreatmentofinflammatoryboweldiseaseanoverview