Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF(V600E): Design, Synthesis, and Antiproliferative Activity

A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR and BRAF(V600E). These hybrid compounds were tested in vitro against four different cancer cell lines. Compounds 8, 9, 18, and 19 inhibited...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Hisham, Mohamed, Abou-Zied, Hesham A., Hassan, Heba A., Youssif, Bahaa G. M., Bräse, Stefan, Hayallah, Alaa M., Abdel-Aziz, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674657/
https://www.ncbi.nlm.nih.gov/pubmed/38004388
http://dx.doi.org/10.3390/ph16111522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674657/
https://www.ncbi.nlm.nih.gov/pubmed/38004388
http://dx.doi.org/10.3390/ph16111522

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