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Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events

Background: Although many adverse reactions after SARS-CoV-2 vaccination have been reported, there have been few comprehensive studies on persistent symptoms after SARS-CoV-2 vaccination. The aim of this study was to determine the clinical characteristics of patients with various persistent symptoms...

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Autores principales: Tokumasu, Kazuki, Fujita-Yamashita, Manami, Sunada, Naruhiko, Sakurada, Yasue, Yamamoto, Koichiro, Nakano, Yasuhiro, Matsuda, Yui, Otsuka, Yuki, Hasegawa, Toru, Hagiya, Hideharu, Honda, Hiroyuki, Otsuka, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674662/
https://www.ncbi.nlm.nih.gov/pubmed/38005993
http://dx.doi.org/10.3390/vaccines11111661
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author Tokumasu, Kazuki
Fujita-Yamashita, Manami
Sunada, Naruhiko
Sakurada, Yasue
Yamamoto, Koichiro
Nakano, Yasuhiro
Matsuda, Yui
Otsuka, Yuki
Hasegawa, Toru
Hagiya, Hideharu
Honda, Hiroyuki
Otsuka, Fumio
author_facet Tokumasu, Kazuki
Fujita-Yamashita, Manami
Sunada, Naruhiko
Sakurada, Yasue
Yamamoto, Koichiro
Nakano, Yasuhiro
Matsuda, Yui
Otsuka, Yuki
Hasegawa, Toru
Hagiya, Hideharu
Honda, Hiroyuki
Otsuka, Fumio
author_sort Tokumasu, Kazuki
collection PubMed
description Background: Although many adverse reactions after SARS-CoV-2 vaccination have been reported, there have been few comprehensive studies on persistent symptoms after SARS-CoV-2 vaccination. The aim of this study was to determine the clinical characteristics of patients with various persistent symptoms after SARS-CoV-2 vaccination. Methods: A retrospective descriptive study was performed for patients who visited a specialized clinic established at Okayama University Hospital to evaluate adverse events after SARS-CoV-2 vaccination during the period from April 2021 to March 2023. Results: Descriptive analysis was performed for 121 of 127 patients who visited the clinic during the study period, and separate analysis was performed for the other 6 patients who had serious complications, who required treatment with prednisolone, and who had persistent symptoms. The median [interquartile range] age of the patients was 48 years [31–64 years], and the patients included 44 males (36.4%) and 77 females (63.6%). The most frequent symptoms were sensory impairment (34 patients, 28.1%), general fatigue (30 patients, 24.8%), fever/low-grade fever (21 patients, 17.4%), and headache (21 patients, 17.4%). Serious complications included myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), sarcoidosis, aseptic meningitis, neuromyelitis optica spectrum disorders (NMOSDs), tendon adhesions, and idiopathic thrombocytopenia. Conclusions: Although causal relationships were not determined, 15 persistent symptoms after SARS-CoV-2 vaccination were characterized. All of the symptoms had onset from 12 hours to one week after vaccination, with 10 symptoms persisting for 6 months or longer. The most frequent symptom was sensory impairment.
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spelling pubmed-106746622023-10-30 Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events Tokumasu, Kazuki Fujita-Yamashita, Manami Sunada, Naruhiko Sakurada, Yasue Yamamoto, Koichiro Nakano, Yasuhiro Matsuda, Yui Otsuka, Yuki Hasegawa, Toru Hagiya, Hideharu Honda, Hiroyuki Otsuka, Fumio Vaccines (Basel) Article Background: Although many adverse reactions after SARS-CoV-2 vaccination have been reported, there have been few comprehensive studies on persistent symptoms after SARS-CoV-2 vaccination. The aim of this study was to determine the clinical characteristics of patients with various persistent symptoms after SARS-CoV-2 vaccination. Methods: A retrospective descriptive study was performed for patients who visited a specialized clinic established at Okayama University Hospital to evaluate adverse events after SARS-CoV-2 vaccination during the period from April 2021 to March 2023. Results: Descriptive analysis was performed for 121 of 127 patients who visited the clinic during the study period, and separate analysis was performed for the other 6 patients who had serious complications, who required treatment with prednisolone, and who had persistent symptoms. The median [interquartile range] age of the patients was 48 years [31–64 years], and the patients included 44 males (36.4%) and 77 females (63.6%). The most frequent symptoms were sensory impairment (34 patients, 28.1%), general fatigue (30 patients, 24.8%), fever/low-grade fever (21 patients, 17.4%), and headache (21 patients, 17.4%). Serious complications included myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), sarcoidosis, aseptic meningitis, neuromyelitis optica spectrum disorders (NMOSDs), tendon adhesions, and idiopathic thrombocytopenia. Conclusions: Although causal relationships were not determined, 15 persistent symptoms after SARS-CoV-2 vaccination were characterized. All of the symptoms had onset from 12 hours to one week after vaccination, with 10 symptoms persisting for 6 months or longer. The most frequent symptom was sensory impairment. MDPI 2023-10-30 /pmc/articles/PMC10674662/ /pubmed/38005993 http://dx.doi.org/10.3390/vaccines11111661 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tokumasu, Kazuki
Fujita-Yamashita, Manami
Sunada, Naruhiko
Sakurada, Yasue
Yamamoto, Koichiro
Nakano, Yasuhiro
Matsuda, Yui
Otsuka, Yuki
Hasegawa, Toru
Hagiya, Hideharu
Honda, Hiroyuki
Otsuka, Fumio
Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events
title Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events
title_full Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events
title_fullStr Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events
title_full_unstemmed Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events
title_short Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events
title_sort characteristics of persistent symptoms manifested after sars-cov-2 vaccination: an observational retrospective study in a specialized clinic for vaccination-related adverse events
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674662/
https://www.ncbi.nlm.nih.gov/pubmed/38005993
http://dx.doi.org/10.3390/vaccines11111661
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