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Does the Human Gut Virome Contribute to Host Health or Disease?
The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674713/ https://www.ncbi.nlm.nih.gov/pubmed/38005947 http://dx.doi.org/10.3390/v15112271 |
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author | Pavia, Grazia Marascio, Nadia Matera, Giovanni Quirino, Angela |
author_facet | Pavia, Grazia Marascio, Nadia Matera, Giovanni Quirino, Angela |
author_sort | Pavia, Grazia |
collection | PubMed |
description | The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cross communication between mucosal immunity and the gut virome, as well as their relationship in health and disease, remain largely unknown. Herein, we review the literature on the human gut virome’s composition and evolution and the interplay between the gut virome and enteric mucosal immunity and their molecular mechanisms. Our review suggests that future research efforts should focus on unraveling the mechanisms of gut viruses in human homeostasis and pathophysiology and on developing virus-prompted precision therapies. |
format | Online Article Text |
id | pubmed-10674713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106747132023-11-17 Does the Human Gut Virome Contribute to Host Health or Disease? Pavia, Grazia Marascio, Nadia Matera, Giovanni Quirino, Angela Viruses Review The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cross communication between mucosal immunity and the gut virome, as well as their relationship in health and disease, remain largely unknown. Herein, we review the literature on the human gut virome’s composition and evolution and the interplay between the gut virome and enteric mucosal immunity and their molecular mechanisms. Our review suggests that future research efforts should focus on unraveling the mechanisms of gut viruses in human homeostasis and pathophysiology and on developing virus-prompted precision therapies. MDPI 2023-11-17 /pmc/articles/PMC10674713/ /pubmed/38005947 http://dx.doi.org/10.3390/v15112271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pavia, Grazia Marascio, Nadia Matera, Giovanni Quirino, Angela Does the Human Gut Virome Contribute to Host Health or Disease? |
title | Does the Human Gut Virome Contribute to Host Health or Disease? |
title_full | Does the Human Gut Virome Contribute to Host Health or Disease? |
title_fullStr | Does the Human Gut Virome Contribute to Host Health or Disease? |
title_full_unstemmed | Does the Human Gut Virome Contribute to Host Health or Disease? |
title_short | Does the Human Gut Virome Contribute to Host Health or Disease? |
title_sort | does the human gut virome contribute to host health or disease? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674713/ https://www.ncbi.nlm.nih.gov/pubmed/38005947 http://dx.doi.org/10.3390/v15112271 |
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