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Does the Human Gut Virome Contribute to Host Health or Disease?

The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cr...

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Detalles Bibliográficos
Autores principales: Pavia, Grazia, Marascio, Nadia, Matera, Giovanni, Quirino, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674713/
https://www.ncbi.nlm.nih.gov/pubmed/38005947
http://dx.doi.org/10.3390/v15112271
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author Pavia, Grazia
Marascio, Nadia
Matera, Giovanni
Quirino, Angela
author_facet Pavia, Grazia
Marascio, Nadia
Matera, Giovanni
Quirino, Angela
author_sort Pavia, Grazia
collection PubMed
description The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cross communication between mucosal immunity and the gut virome, as well as their relationship in health and disease, remain largely unknown. Herein, we review the literature on the human gut virome’s composition and evolution and the interplay between the gut virome and enteric mucosal immunity and their molecular mechanisms. Our review suggests that future research efforts should focus on unraveling the mechanisms of gut viruses in human homeostasis and pathophysiology and on developing virus-prompted precision therapies.
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spelling pubmed-106747132023-11-17 Does the Human Gut Virome Contribute to Host Health or Disease? Pavia, Grazia Marascio, Nadia Matera, Giovanni Quirino, Angela Viruses Review The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cross communication between mucosal immunity and the gut virome, as well as their relationship in health and disease, remain largely unknown. Herein, we review the literature on the human gut virome’s composition and evolution and the interplay between the gut virome and enteric mucosal immunity and their molecular mechanisms. Our review suggests that future research efforts should focus on unraveling the mechanisms of gut viruses in human homeostasis and pathophysiology and on developing virus-prompted precision therapies. MDPI 2023-11-17 /pmc/articles/PMC10674713/ /pubmed/38005947 http://dx.doi.org/10.3390/v15112271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pavia, Grazia
Marascio, Nadia
Matera, Giovanni
Quirino, Angela
Does the Human Gut Virome Contribute to Host Health or Disease?
title Does the Human Gut Virome Contribute to Host Health or Disease?
title_full Does the Human Gut Virome Contribute to Host Health or Disease?
title_fullStr Does the Human Gut Virome Contribute to Host Health or Disease?
title_full_unstemmed Does the Human Gut Virome Contribute to Host Health or Disease?
title_short Does the Human Gut Virome Contribute to Host Health or Disease?
title_sort does the human gut virome contribute to host health or disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674713/
https://www.ncbi.nlm.nih.gov/pubmed/38005947
http://dx.doi.org/10.3390/v15112271
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