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Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays

Although studies have demonstrated that infections with various viruses, bacteria, and parasites can modulate the immune system, no study has investigated changes in antibodies against microbial antigens after the COVID-19 mRNA vaccination. IgG antibodies against microbial antigens in the blood of v...

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Autores principales: Saito, Hiroaki, Yoshimura, Hiroki, Yoshida, Makoto, Tani, Yuta, Kawashima, Moe, Uchiyama, Taiga, Zhao, Tianchen, Yamamoto, Chika, Kobashi, Yurie, Sawano, Toyoaki, Imoto, Seiya, Park, Hyeongki, Nakamura, Naotoshi, Iwami, Shingo, Kaneko, Yudai, Nakayama, Aya, Kodama, Tatsuhiko, Wakui, Masatoshi, Kawamura, Takeshi, Tsubokura, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674746/
https://www.ncbi.nlm.nih.gov/pubmed/38006026
http://dx.doi.org/10.3390/vaccines11111694
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author Saito, Hiroaki
Yoshimura, Hiroki
Yoshida, Makoto
Tani, Yuta
Kawashima, Moe
Uchiyama, Taiga
Zhao, Tianchen
Yamamoto, Chika
Kobashi, Yurie
Sawano, Toyoaki
Imoto, Seiya
Park, Hyeongki
Nakamura, Naotoshi
Iwami, Shingo
Kaneko, Yudai
Nakayama, Aya
Kodama, Tatsuhiko
Wakui, Masatoshi
Kawamura, Takeshi
Tsubokura, Masaharu
author_facet Saito, Hiroaki
Yoshimura, Hiroki
Yoshida, Makoto
Tani, Yuta
Kawashima, Moe
Uchiyama, Taiga
Zhao, Tianchen
Yamamoto, Chika
Kobashi, Yurie
Sawano, Toyoaki
Imoto, Seiya
Park, Hyeongki
Nakamura, Naotoshi
Iwami, Shingo
Kaneko, Yudai
Nakayama, Aya
Kodama, Tatsuhiko
Wakui, Masatoshi
Kawamura, Takeshi
Tsubokura, Masaharu
author_sort Saito, Hiroaki
collection PubMed
description Although studies have demonstrated that infections with various viruses, bacteria, and parasites can modulate the immune system, no study has investigated changes in antibodies against microbial antigens after the COVID-19 mRNA vaccination. IgG antibodies against microbial antigens in the blood of vaccinees were comprehensively analyzed using microbial protein microarrays that carried approximately 5000 microbe-derived proteins. Changes in antibodies against microbial antigens were scrutinized in healthy participants enrolled in the Fukushima Vaccination Community Survey conducted in Fukushima Prefecture, Japan, after their second and third COVID-19 mRNA vaccinations. Antibody profiling of six groups stratified by antibody titer and the remaining neutralizing antibodies was also performed to study the dynamics of neutralizing antibodies against SARS-CoV-2 and the changes in antibodies against microbial antigens. The results showed that changes in antibodies against microbial antigens other than SARS-CoV-2 antigens were extremely limited after COVID-19 vaccination. In addition, antibodies against a staphylococcal complement inhibitor have been identified as microbial antigens that are associated with increased levels of neutralizing antibodies against SARS-CoV-2. These antibodies may be a predictor of the maintenance of neutralizing antibodies following the administration of a COVID-19 mRNA vaccine.
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spelling pubmed-106747462023-11-07 Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays Saito, Hiroaki Yoshimura, Hiroki Yoshida, Makoto Tani, Yuta Kawashima, Moe Uchiyama, Taiga Zhao, Tianchen Yamamoto, Chika Kobashi, Yurie Sawano, Toyoaki Imoto, Seiya Park, Hyeongki Nakamura, Naotoshi Iwami, Shingo Kaneko, Yudai Nakayama, Aya Kodama, Tatsuhiko Wakui, Masatoshi Kawamura, Takeshi Tsubokura, Masaharu Vaccines (Basel) Article Although studies have demonstrated that infections with various viruses, bacteria, and parasites can modulate the immune system, no study has investigated changes in antibodies against microbial antigens after the COVID-19 mRNA vaccination. IgG antibodies against microbial antigens in the blood of vaccinees were comprehensively analyzed using microbial protein microarrays that carried approximately 5000 microbe-derived proteins. Changes in antibodies against microbial antigens were scrutinized in healthy participants enrolled in the Fukushima Vaccination Community Survey conducted in Fukushima Prefecture, Japan, after their second and third COVID-19 mRNA vaccinations. Antibody profiling of six groups stratified by antibody titer and the remaining neutralizing antibodies was also performed to study the dynamics of neutralizing antibodies against SARS-CoV-2 and the changes in antibodies against microbial antigens. The results showed that changes in antibodies against microbial antigens other than SARS-CoV-2 antigens were extremely limited after COVID-19 vaccination. In addition, antibodies against a staphylococcal complement inhibitor have been identified as microbial antigens that are associated with increased levels of neutralizing antibodies against SARS-CoV-2. These antibodies may be a predictor of the maintenance of neutralizing antibodies following the administration of a COVID-19 mRNA vaccine. MDPI 2023-11-07 /pmc/articles/PMC10674746/ /pubmed/38006026 http://dx.doi.org/10.3390/vaccines11111694 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saito, Hiroaki
Yoshimura, Hiroki
Yoshida, Makoto
Tani, Yuta
Kawashima, Moe
Uchiyama, Taiga
Zhao, Tianchen
Yamamoto, Chika
Kobashi, Yurie
Sawano, Toyoaki
Imoto, Seiya
Park, Hyeongki
Nakamura, Naotoshi
Iwami, Shingo
Kaneko, Yudai
Nakayama, Aya
Kodama, Tatsuhiko
Wakui, Masatoshi
Kawamura, Takeshi
Tsubokura, Masaharu
Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays
title Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays
title_full Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays
title_fullStr Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays
title_full_unstemmed Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays
title_short Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays
title_sort antibody profiling of microbial antigens in the blood of covid-19 mrna vaccine recipients using microbial protein microarrays
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674746/
https://www.ncbi.nlm.nih.gov/pubmed/38006026
http://dx.doi.org/10.3390/vaccines11111694
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