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Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study

People with HIV (PWH) incur a higher risk of COVID-19-related morbidity and mortality rates, yet less is known about COVID-19 vaccine uptake and hesitancy in this group. We conducted a cross-sectional study in Freetown, Sierra Leone, from April to June 2022, using the VAX scale, a validated instrume...

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Autores principales: Cummings, Peterlyn E., Lakoh, Sulaiman, Yendewa, Sahr A., Massaquoi, Samuel P. E., James, Peter B., Sahr, Foday, Deen, Gibrilla F., Salata, Robert A., Gevao, Pelema, Yendewa, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674940/
https://www.ncbi.nlm.nih.gov/pubmed/38006017
http://dx.doi.org/10.3390/vaccines11111685
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author Cummings, Peterlyn E.
Lakoh, Sulaiman
Yendewa, Sahr A.
Massaquoi, Samuel P. E.
James, Peter B.
Sahr, Foday
Deen, Gibrilla F.
Salata, Robert A.
Gevao, Pelema
Yendewa, George A.
author_facet Cummings, Peterlyn E.
Lakoh, Sulaiman
Yendewa, Sahr A.
Massaquoi, Samuel P. E.
James, Peter B.
Sahr, Foday
Deen, Gibrilla F.
Salata, Robert A.
Gevao, Pelema
Yendewa, George A.
author_sort Cummings, Peterlyn E.
collection PubMed
description People with HIV (PWH) incur a higher risk of COVID-19-related morbidity and mortality rates, yet less is known about COVID-19 vaccine uptake and hesitancy in this group. We conducted a cross-sectional study in Freetown, Sierra Leone, from April to June 2022, using the VAX scale, a validated instrument, to assess attitudes towards COVID-19 vaccination and calculate the hesitancy (VAX) scores. We used generalized linear models to identify the factors associated with vaccine hesitancy. Overall, 490 PWH were enrolled (71.4% female, median age: 38 years, median CD4 count: 412 cells/mm(3)). About 17.3% received ≥1 dose of a COVID-19 vaccine. The mean VAX score was 43.14 ± 7.05, corresponding to 59.9% participants being vaccine-hesitant. A preference for natural immunity (65.8%) and concerns about profiteering (64.4%) were the commonest reasons for hesitancy, followed by a mistrust of vaccine benefits (61.4%) and worries about future effects (48.0%). In the adjusted regression analysis, being a Muslim (β = 2.563, p < 0.001) and having an urban residence (β = 1.709, p = 0.010) were associated with greater vaccine hesitancy, while testing for COVID-19 was associated with reduced vaccine hesitancy (β = −3.417, p = 0.027). These findings underscore the importance of addressing vaccine hesitancy as a critical element boosting COVID-19 vaccine uptake among PWH.
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spelling pubmed-106749402023-11-02 Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study Cummings, Peterlyn E. Lakoh, Sulaiman Yendewa, Sahr A. Massaquoi, Samuel P. E. James, Peter B. Sahr, Foday Deen, Gibrilla F. Salata, Robert A. Gevao, Pelema Yendewa, George A. Vaccines (Basel) Article People with HIV (PWH) incur a higher risk of COVID-19-related morbidity and mortality rates, yet less is known about COVID-19 vaccine uptake and hesitancy in this group. We conducted a cross-sectional study in Freetown, Sierra Leone, from April to June 2022, using the VAX scale, a validated instrument, to assess attitudes towards COVID-19 vaccination and calculate the hesitancy (VAX) scores. We used generalized linear models to identify the factors associated with vaccine hesitancy. Overall, 490 PWH were enrolled (71.4% female, median age: 38 years, median CD4 count: 412 cells/mm(3)). About 17.3% received ≥1 dose of a COVID-19 vaccine. The mean VAX score was 43.14 ± 7.05, corresponding to 59.9% participants being vaccine-hesitant. A preference for natural immunity (65.8%) and concerns about profiteering (64.4%) were the commonest reasons for hesitancy, followed by a mistrust of vaccine benefits (61.4%) and worries about future effects (48.0%). In the adjusted regression analysis, being a Muslim (β = 2.563, p < 0.001) and having an urban residence (β = 1.709, p = 0.010) were associated with greater vaccine hesitancy, while testing for COVID-19 was associated with reduced vaccine hesitancy (β = −3.417, p = 0.027). These findings underscore the importance of addressing vaccine hesitancy as a critical element boosting COVID-19 vaccine uptake among PWH. MDPI 2023-11-02 /pmc/articles/PMC10674940/ /pubmed/38006017 http://dx.doi.org/10.3390/vaccines11111685 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cummings, Peterlyn E.
Lakoh, Sulaiman
Yendewa, Sahr A.
Massaquoi, Samuel P. E.
James, Peter B.
Sahr, Foday
Deen, Gibrilla F.
Salata, Robert A.
Gevao, Pelema
Yendewa, George A.
Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study
title Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study
title_full Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study
title_fullStr Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study
title_full_unstemmed Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study
title_short Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study
title_sort understanding covid-19 vaccine uptake and hesitancy among people with hiv in freetown, sierra leone: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674940/
https://www.ncbi.nlm.nih.gov/pubmed/38006017
http://dx.doi.org/10.3390/vaccines11111685
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