Cargando…

Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach

Metabolic syndrome (MetS) is a global issue affecting over a billion people, raising the risk of diabetes, cardiovascular disorders, and other ailments. It is often characterized by hypertension, dyslipidemia and/or obesity, and hyperglycemia. Chemical investigation of Aeonium arboreum (L.) Webb &am...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfeqy, Marwah M., El-Hawary, Seham S., El-Halawany, Ali M., Rabeh, Mohamed A., Alshehri, Saad A., Serry, Aya M., Fahmy, Heba A., Ezzat, Marwa. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675073/
https://www.ncbi.nlm.nih.gov/pubmed/38004522
http://dx.doi.org/10.3390/pharmaceutics15112541
_version_ 1785140978268504064
author Alfeqy, Marwah M.
El-Hawary, Seham S.
El-Halawany, Ali M.
Rabeh, Mohamed A.
Alshehri, Saad A.
Serry, Aya M.
Fahmy, Heba A.
Ezzat, Marwa. I.
author_facet Alfeqy, Marwah M.
El-Hawary, Seham S.
El-Halawany, Ali M.
Rabeh, Mohamed A.
Alshehri, Saad A.
Serry, Aya M.
Fahmy, Heba A.
Ezzat, Marwa. I.
author_sort Alfeqy, Marwah M.
collection PubMed
description Metabolic syndrome (MetS) is a global issue affecting over a billion people, raising the risk of diabetes, cardiovascular disorders, and other ailments. It is often characterized by hypertension, dyslipidemia and/or obesity, and hyperglycemia. Chemical investigation of Aeonium arboreum (L.) Webb & Berthel led to the isolation of six compounds, viz. β-sitosterol, β-sitosterol glucoside, myricetin galactoside, quercetin rhamnoside, kaempferol rhamnoside, and myricetin glucoside. Interestingly, A. arboreum’s dichloromethane (DCM), 100 and 50% MeOH Diaion fractions and the isolated compound (quercetin-3-rhamnoside) revealed potent α-glucosidase inhibitory activity, especially 50% Diaion fraction. In addition, they also showed very potent antioxidant potential, especially the polar fractions, using DPPH, ABTS, FRAP, ORAC, and metal chelation assays. Notably, the 50% Diaion fraction had the highest antioxidant potential using DPPH and ORAC assays, while the 100% Diaion fraction and quercetin-3-rhamnoside showed the highest activity using ABTS, FRAP, and metal chelation assays. Also, quercetin-3-rhamnoside showed a good docking score of −5.82 kcal/mol in comparison to acarbose. In addition, molecular dynamic stimulation studies illustrated high stability of compound binding to pocket of protein. Such potent activities present A. arboreum as a complementary safe approach for the management of diabetes mellitus as well as MetS.
format Online
Article
Text
id pubmed-10675073
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106750732023-10-27 Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach Alfeqy, Marwah M. El-Hawary, Seham S. El-Halawany, Ali M. Rabeh, Mohamed A. Alshehri, Saad A. Serry, Aya M. Fahmy, Heba A. Ezzat, Marwa. I. Pharmaceutics Article Metabolic syndrome (MetS) is a global issue affecting over a billion people, raising the risk of diabetes, cardiovascular disorders, and other ailments. It is often characterized by hypertension, dyslipidemia and/or obesity, and hyperglycemia. Chemical investigation of Aeonium arboreum (L.) Webb & Berthel led to the isolation of six compounds, viz. β-sitosterol, β-sitosterol glucoside, myricetin galactoside, quercetin rhamnoside, kaempferol rhamnoside, and myricetin glucoside. Interestingly, A. arboreum’s dichloromethane (DCM), 100 and 50% MeOH Diaion fractions and the isolated compound (quercetin-3-rhamnoside) revealed potent α-glucosidase inhibitory activity, especially 50% Diaion fraction. In addition, they also showed very potent antioxidant potential, especially the polar fractions, using DPPH, ABTS, FRAP, ORAC, and metal chelation assays. Notably, the 50% Diaion fraction had the highest antioxidant potential using DPPH and ORAC assays, while the 100% Diaion fraction and quercetin-3-rhamnoside showed the highest activity using ABTS, FRAP, and metal chelation assays. Also, quercetin-3-rhamnoside showed a good docking score of −5.82 kcal/mol in comparison to acarbose. In addition, molecular dynamic stimulation studies illustrated high stability of compound binding to pocket of protein. Such potent activities present A. arboreum as a complementary safe approach for the management of diabetes mellitus as well as MetS. MDPI 2023-10-27 /pmc/articles/PMC10675073/ /pubmed/38004522 http://dx.doi.org/10.3390/pharmaceutics15112541 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alfeqy, Marwah M.
El-Hawary, Seham S.
El-Halawany, Ali M.
Rabeh, Mohamed A.
Alshehri, Saad A.
Serry, Aya M.
Fahmy, Heba A.
Ezzat, Marwa. I.
Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
title Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
title_full Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
title_fullStr Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
title_full_unstemmed Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
title_short Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
title_sort effect of phenolics from aeonium arboreum on alpha glucosidase, pancreatic lipase, and oxidative stress; a bio-guided approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675073/
https://www.ncbi.nlm.nih.gov/pubmed/38004522
http://dx.doi.org/10.3390/pharmaceutics15112541
work_keys_str_mv AT alfeqymarwahm effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT elhawarysehams effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT elhalawanyalim effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT rabehmohameda effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT alshehrisaada effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT serryayam effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT fahmyhebaa effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach
AT ezzatmarwai effectofphenolicsfromaeoniumarboreumonalphaglucosidasepancreaticlipaseandoxidativestressabioguidedapproach