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Design, Synthesis, and Repurposing of Rosmarinic Acid-β-Amino-α-Ketoamide Hybrids as Antileishmanial Agents

A series of rosmarinic acid-β-amino-α-ketoamide hybrids were synthesized and rationally repurposed towards the identification of new antileishmanial hit compounds. Two hybrids, 2g and 2h, showed promising activity (IC(50) values of 9.5 and 8.8 μM against Leishmania donovani promastigotes, respective...

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Detalles Bibliográficos
Autores principales:	Hassan, Ahmed H.E., Bayoumi, Waleed A., El-Sayed, Selwan M., Phan, Trong-Nhat, Oh, Taegeun, Ham, Gyeongpyo, Mahmoud, Kazem, No, Joo Hwan, Lee, Yong Sup
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675174/ https://www.ncbi.nlm.nih.gov/pubmed/38004459 http://dx.doi.org/10.3390/ph16111594

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