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Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan

The presence of lipoarabinomannan (LAM) in the Mycobacterium tuberculosis (Mtb) cell envelope was first reported close to 100 years ago. Since then, numerous studies have been dedicated to the isolation, purification, structural definition, and elucidation of the biological properties of Mtb LAM. In...

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Autores principales: Torrelles, Jordi B., Chatterjee, Delphi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675199/
https://www.ncbi.nlm.nih.gov/pubmed/38003746
http://dx.doi.org/10.3390/pathogens12111281
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author Torrelles, Jordi B.
Chatterjee, Delphi
author_facet Torrelles, Jordi B.
Chatterjee, Delphi
author_sort Torrelles, Jordi B.
collection PubMed
description The presence of lipoarabinomannan (LAM) in the Mycobacterium tuberculosis (Mtb) cell envelope was first reported close to 100 years ago. Since then, numerous studies have been dedicated to the isolation, purification, structural definition, and elucidation of the biological properties of Mtb LAM. In this review, we present a brief historical perspective on the discovery of Mtb LAM and the herculean efforts devoted to structurally characterizing the molecule because of its unique structural and biological features. The significance of LAM remains high to this date, mainly due to its distinct immunological properties in conjunction with its role as a biomarker for diagnostic tests due to its identification in urine, and thus can serve as a point-of-care diagnostic test for tuberculosis (TB). In recent decades, LAM has been thoroughly studied and massive amounts of information on this intriguing molecule are now available. In this review, we give the readers a historical perspective and an update on the current knowledge of LAM with information on the inherent carbohydrate composition, which is unique due to the often puzzling sugar residues that are specifically found on LAM. We then guide the readers through the complex and myriad immunological outcomes, which are strictly dependent on LAM’s chemical structure. Furthermore, we present issues that remain unresolved and represent the immediate future of LAM research. Addressing the chemistry, functions, and roles of LAM will lead to innovative ways to manipulate the processes that involve this controversial and fascinating biomolecule.
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spelling pubmed-106751992023-10-26 Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan Torrelles, Jordi B. Chatterjee, Delphi Pathogens Review The presence of lipoarabinomannan (LAM) in the Mycobacterium tuberculosis (Mtb) cell envelope was first reported close to 100 years ago. Since then, numerous studies have been dedicated to the isolation, purification, structural definition, and elucidation of the biological properties of Mtb LAM. In this review, we present a brief historical perspective on the discovery of Mtb LAM and the herculean efforts devoted to structurally characterizing the molecule because of its unique structural and biological features. The significance of LAM remains high to this date, mainly due to its distinct immunological properties in conjunction with its role as a biomarker for diagnostic tests due to its identification in urine, and thus can serve as a point-of-care diagnostic test for tuberculosis (TB). In recent decades, LAM has been thoroughly studied and massive amounts of information on this intriguing molecule are now available. In this review, we give the readers a historical perspective and an update on the current knowledge of LAM with information on the inherent carbohydrate composition, which is unique due to the often puzzling sugar residues that are specifically found on LAM. We then guide the readers through the complex and myriad immunological outcomes, which are strictly dependent on LAM’s chemical structure. Furthermore, we present issues that remain unresolved and represent the immediate future of LAM research. Addressing the chemistry, functions, and roles of LAM will lead to innovative ways to manipulate the processes that involve this controversial and fascinating biomolecule. MDPI 2023-10-26 /pmc/articles/PMC10675199/ /pubmed/38003746 http://dx.doi.org/10.3390/pathogens12111281 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Torrelles, Jordi B.
Chatterjee, Delphi
Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
title Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
title_full Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
title_fullStr Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
title_full_unstemmed Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
title_short Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
title_sort collected thoughts on mycobacterial lipoarabinomannan, a cell envelope lipoglycan
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675199/
https://www.ncbi.nlm.nih.gov/pubmed/38003746
http://dx.doi.org/10.3390/pathogens12111281
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