Novel Auger-Electron-Emitting (191)Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma

Auger electrons can cause nanoscale physiochemical damage to specific DNA sites that play a key role in cancer cell survival. Radio-Pt is a promising Auger-electron source for damaging DNA efficiently because of its ability to bind to DNA. Considering that the cancer genome is maintained under abnor...

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Detalles Bibliográficos
Autores principales: Obata, Honoka, Tsuji, Atsushi B., Sudo, Hitomi, Sugyo, Aya, Hashiya, Kaori, Ikeda, Hayato, Itoh, Masatoshi, Minegishi, Katsuyuki, Nagatsu, Kotaro, Ogawa, Mikako, Bando, Toshikazu, Sugiyama, Hiroshi, Zhang, Ming-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675227/
https://www.ncbi.nlm.nih.gov/pubmed/38004392
http://dx.doi.org/10.3390/ph16111526

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