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A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients

Tacrolimus is the principal immunosuppressive drug which is administered after heart transplantation. Managing tacrolimus therapy is challenging due to a narrow therapeutic index and wide pharmacokinetic (PK) variability. We aimed to establish a physiologically based pharmacokinetic (PBPK) model of...

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Detalles Bibliográficos
Autores principales:	Pei, Ling, Li, Run, Zhou, Hong, Du, Wenxin, Gu, Yajie, Jiang, Yingshuo, Wang, Yongqing, Chen, Xin, Sun, Jianguo, Zhu, Junrong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675244/ https://www.ncbi.nlm.nih.gov/pubmed/38004558 http://dx.doi.org/10.3390/pharmaceutics15112580

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