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Association of Single-Nucleotide Polymorphisms in Capecitabine Bioactivation Pathway with Adjuvant Therapy Safety in Colorectal Cancer Patients

Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), is part of the standard treatment of colorectal cancer (CRC). Severe adverse dose limiting reactions that impair treatment safety and lead to treatment suspension remain a relevant concern. Single-nucleotide polymorphisms (SNPs) in genes involv...

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Detalles Bibliográficos
Autores principales:	Cura, Yasmin, Sánchez-Martín, Almudena, Márquez-Pete, Noelia, González-Flores, Encarnación, Martínez-Martínez, Fernando, Pérez-Ramírez, Cristina, Jiménez-Morales, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675271/ https://www.ncbi.nlm.nih.gov/pubmed/38004528 http://dx.doi.org/10.3390/pharmaceutics15112548

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