Intranasal Liposomal Formulation of Spike Protein Adjuvanted with CpG Protects and Boosts Heterologous Immunity of hACE2 Transgenic Mice to SARS-CoV-2 Infection

Mucosal vaccination appears to be suitable to protect against SARS-CoV-2 infection. In this study, we tested an intranasal mucosal vaccine candidate for COVID-19 that consisted of a cationic liposome containing a trimeric SARS-CoV-2 spike protein and CpG-ODNs, a Toll-like receptor 9 agonist, as an a...

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Detalles Bibliográficos
Autores principales: Russo, Momtchilo, Mendes-Corrêa, Maria Cássia, Lins, Bruna B., Kersten, Victor, Pernambuco Filho, Paulo C. A., Martins, Toni Ricardo, Tozetto-Mendoza, Tânia Regina, Vilas Boas, Lucy Santos, Gomes, Brisa Moreira, Dati, Livia Mendonça Munhoz, Duarte-Neto, Amaro Nunes, Reigado, Gustavo Roncoli, Frederico, Ana Beatriz T., de Brito e Cunha, Danielle R. de A., de Paula, Anderson Vicente, da Silva, José Igor G., Vasconcelos, Carlos F. Moreira, Chambergo, Felipe S., Nunes, Viviane Abreu, Ano Bom, Ana Paula Dinis, Castilho, Leda R., Martins, Rodrigo A. P., Hirata, Mario Hiroyuki, Mirotti, Luciana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675295/
https://www.ncbi.nlm.nih.gov/pubmed/38006064
http://dx.doi.org/10.3390/vaccines11111732

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