Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature

A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh(3) at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd(2)(dba)(3)·CHCl(3) and the phosphine ligand (Me)CgPPh having an adamantane-like framework. The p...

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Detalles Bibliográficos
Autores principales: Zayakin, Igor, Romanenko, Galina, Bagryanskaya, Irina, Ugrak, Bogdan, Fedin, Matvey, Tretyakov, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675334/
https://www.ncbi.nlm.nih.gov/pubmed/38005383
http://dx.doi.org/10.3390/molecules28227661
Descripción
Sumario:A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh(3) at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd(2)(dba)(3)·CHCl(3) and the phosphine ligand (Me)CgPPh having an adamantane-like framework. The present protocol was found to be well compatible with various heteroaryl iodides, thus opening new horizons in directed synthesis of functionalized nitronyl nitroxides and high-spin molecules.

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