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Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
Objectives: Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, pre...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675417/ https://www.ncbi.nlm.nih.gov/pubmed/38005820 http://dx.doi.org/10.3390/v15112142 |
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author | Rybak-Krzyszkowska, Magda Górecka, Joanna Huras, Hubert Massalska-Wolska, Magdalena Staśkiewicz, Magdalena Gach, Agnieszka Kondracka, Adrianna Staniczek, Jakub Górczewski, Wojciech Borowski, Dariusz Jaczyńska, Renata Grzesiak, Mariusz Krzeszowski, Waldemar |
author_facet | Rybak-Krzyszkowska, Magda Górecka, Joanna Huras, Hubert Massalska-Wolska, Magdalena Staśkiewicz, Magdalena Gach, Agnieszka Kondracka, Adrianna Staniczek, Jakub Górczewski, Wojciech Borowski, Dariusz Jaczyńska, Renata Grzesiak, Mariusz Krzeszowski, Waldemar |
author_sort | Rybak-Krzyszkowska, Magda |
collection | PubMed |
description | Objectives: Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, prevention mechanisms, and treatment options. Methods: Specifically, information from the Cochrane Library, PUBMED, Wiley Online, Science Direct, and Taylor Francis databases were reviewed along with additional records identified through the register, the Google Scholar search engine. Based on the search, 21 articles were identified for systematic review. Results: A total of six randomized controlled trials (RCTs) were utilized for a meta-analytic review. As heterogeneity was substantial, the random effects model was used for meta-analysis. Utilizing the random-effects model, the restricted maximum likelihood (REML) approach, the estimate of effect size (d = −0.479, 95% CI = −0.977 to 0.019, p = 0.060) suggests the results are not statistically significant, so it cannot be inferred that the prevention methods used were effective, despite an inverse relationship between treatment and number of infected cases. The findings indicated that several techniques are used to prevent, diagnose, and manage CMV infection during pregnancy, including proper hygiene, ultrasound examination (US), magnetic resonance imaging (MRI), amniocentesis, viremia, hyperimmunoglobulin (HIG), and valacyclovir (VACV). Conclusions: The current review has significant implications for addressing CMV infection in pregnancy. Specifically, it provides valuable findings on contemporary management interventions to prevent and treat CMV infection among expectant mothers. Therefore, it allows relevant stakeholders to address these critical health concerns and understand the effectiveness of the proposed prevention and treatment options. |
format | Online Article Text |
id | pubmed-10675417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106754172023-10-24 Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis Rybak-Krzyszkowska, Magda Górecka, Joanna Huras, Hubert Massalska-Wolska, Magdalena Staśkiewicz, Magdalena Gach, Agnieszka Kondracka, Adrianna Staniczek, Jakub Górczewski, Wojciech Borowski, Dariusz Jaczyńska, Renata Grzesiak, Mariusz Krzeszowski, Waldemar Viruses Review Objectives: Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, prevention mechanisms, and treatment options. Methods: Specifically, information from the Cochrane Library, PUBMED, Wiley Online, Science Direct, and Taylor Francis databases were reviewed along with additional records identified through the register, the Google Scholar search engine. Based on the search, 21 articles were identified for systematic review. Results: A total of six randomized controlled trials (RCTs) were utilized for a meta-analytic review. As heterogeneity was substantial, the random effects model was used for meta-analysis. Utilizing the random-effects model, the restricted maximum likelihood (REML) approach, the estimate of effect size (d = −0.479, 95% CI = −0.977 to 0.019, p = 0.060) suggests the results are not statistically significant, so it cannot be inferred that the prevention methods used were effective, despite an inverse relationship between treatment and number of infected cases. The findings indicated that several techniques are used to prevent, diagnose, and manage CMV infection during pregnancy, including proper hygiene, ultrasound examination (US), magnetic resonance imaging (MRI), amniocentesis, viremia, hyperimmunoglobulin (HIG), and valacyclovir (VACV). Conclusions: The current review has significant implications for addressing CMV infection in pregnancy. Specifically, it provides valuable findings on contemporary management interventions to prevent and treat CMV infection among expectant mothers. Therefore, it allows relevant stakeholders to address these critical health concerns and understand the effectiveness of the proposed prevention and treatment options. MDPI 2023-10-24 /pmc/articles/PMC10675417/ /pubmed/38005820 http://dx.doi.org/10.3390/v15112142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rybak-Krzyszkowska, Magda Górecka, Joanna Huras, Hubert Massalska-Wolska, Magdalena Staśkiewicz, Magdalena Gach, Agnieszka Kondracka, Adrianna Staniczek, Jakub Górczewski, Wojciech Borowski, Dariusz Jaczyńska, Renata Grzesiak, Mariusz Krzeszowski, Waldemar Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis |
title | Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis |
title_full | Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis |
title_fullStr | Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis |
title_short | Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis |
title_sort | cytomegalovirus infection in pregnancy prevention and treatment options: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675417/ https://www.ncbi.nlm.nih.gov/pubmed/38005820 http://dx.doi.org/10.3390/v15112142 |
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