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Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis

Objectives: Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, pre...

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Autores principales: Rybak-Krzyszkowska, Magda, Górecka, Joanna, Huras, Hubert, Massalska-Wolska, Magdalena, Staśkiewicz, Magdalena, Gach, Agnieszka, Kondracka, Adrianna, Staniczek, Jakub, Górczewski, Wojciech, Borowski, Dariusz, Jaczyńska, Renata, Grzesiak, Mariusz, Krzeszowski, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675417/
https://www.ncbi.nlm.nih.gov/pubmed/38005820
http://dx.doi.org/10.3390/v15112142
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author Rybak-Krzyszkowska, Magda
Górecka, Joanna
Huras, Hubert
Massalska-Wolska, Magdalena
Staśkiewicz, Magdalena
Gach, Agnieszka
Kondracka, Adrianna
Staniczek, Jakub
Górczewski, Wojciech
Borowski, Dariusz
Jaczyńska, Renata
Grzesiak, Mariusz
Krzeszowski, Waldemar
author_facet Rybak-Krzyszkowska, Magda
Górecka, Joanna
Huras, Hubert
Massalska-Wolska, Magdalena
Staśkiewicz, Magdalena
Gach, Agnieszka
Kondracka, Adrianna
Staniczek, Jakub
Górczewski, Wojciech
Borowski, Dariusz
Jaczyńska, Renata
Grzesiak, Mariusz
Krzeszowski, Waldemar
author_sort Rybak-Krzyszkowska, Magda
collection PubMed
description Objectives: Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, prevention mechanisms, and treatment options. Methods: Specifically, information from the Cochrane Library, PUBMED, Wiley Online, Science Direct, and Taylor Francis databases were reviewed along with additional records identified through the register, the Google Scholar search engine. Based on the search, 21 articles were identified for systematic review. Results: A total of six randomized controlled trials (RCTs) were utilized for a meta-analytic review. As heterogeneity was substantial, the random effects model was used for meta-analysis. Utilizing the random-effects model, the restricted maximum likelihood (REML) approach, the estimate of effect size (d = −0.479, 95% CI = −0.977 to 0.019, p = 0.060) suggests the results are not statistically significant, so it cannot be inferred that the prevention methods used were effective, despite an inverse relationship between treatment and number of infected cases. The findings indicated that several techniques are used to prevent, diagnose, and manage CMV infection during pregnancy, including proper hygiene, ultrasound examination (US), magnetic resonance imaging (MRI), amniocentesis, viremia, hyperimmunoglobulin (HIG), and valacyclovir (VACV). Conclusions: The current review has significant implications for addressing CMV infection in pregnancy. Specifically, it provides valuable findings on contemporary management interventions to prevent and treat CMV infection among expectant mothers. Therefore, it allows relevant stakeholders to address these critical health concerns and understand the effectiveness of the proposed prevention and treatment options.
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spelling pubmed-106754172023-10-24 Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis Rybak-Krzyszkowska, Magda Górecka, Joanna Huras, Hubert Massalska-Wolska, Magdalena Staśkiewicz, Magdalena Gach, Agnieszka Kondracka, Adrianna Staniczek, Jakub Górczewski, Wojciech Borowski, Dariusz Jaczyńska, Renata Grzesiak, Mariusz Krzeszowski, Waldemar Viruses Review Objectives: Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, prevention mechanisms, and treatment options. Methods: Specifically, information from the Cochrane Library, PUBMED, Wiley Online, Science Direct, and Taylor Francis databases were reviewed along with additional records identified through the register, the Google Scholar search engine. Based on the search, 21 articles were identified for systematic review. Results: A total of six randomized controlled trials (RCTs) were utilized for a meta-analytic review. As heterogeneity was substantial, the random effects model was used for meta-analysis. Utilizing the random-effects model, the restricted maximum likelihood (REML) approach, the estimate of effect size (d = −0.479, 95% CI = −0.977 to 0.019, p = 0.060) suggests the results are not statistically significant, so it cannot be inferred that the prevention methods used were effective, despite an inverse relationship between treatment and number of infected cases. The findings indicated that several techniques are used to prevent, diagnose, and manage CMV infection during pregnancy, including proper hygiene, ultrasound examination (US), magnetic resonance imaging (MRI), amniocentesis, viremia, hyperimmunoglobulin (HIG), and valacyclovir (VACV). Conclusions: The current review has significant implications for addressing CMV infection in pregnancy. Specifically, it provides valuable findings on contemporary management interventions to prevent and treat CMV infection among expectant mothers. Therefore, it allows relevant stakeholders to address these critical health concerns and understand the effectiveness of the proposed prevention and treatment options. MDPI 2023-10-24 /pmc/articles/PMC10675417/ /pubmed/38005820 http://dx.doi.org/10.3390/v15112142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rybak-Krzyszkowska, Magda
Górecka, Joanna
Huras, Hubert
Massalska-Wolska, Magdalena
Staśkiewicz, Magdalena
Gach, Agnieszka
Kondracka, Adrianna
Staniczek, Jakub
Górczewski, Wojciech
Borowski, Dariusz
Jaczyńska, Renata
Grzesiak, Mariusz
Krzeszowski, Waldemar
Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
title Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
title_full Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
title_fullStr Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
title_full_unstemmed Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
title_short Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis
title_sort cytomegalovirus infection in pregnancy prevention and treatment options: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675417/
https://www.ncbi.nlm.nih.gov/pubmed/38005820
http://dx.doi.org/10.3390/v15112142
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