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Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study

Background: The increased vascular risk associated with varicella–zoster virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds for People Living with HIV (PLWH), a group already confronting heightene...

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Autores principales: Fiordelisi, Deborah, Poliseno, Mariacristina, De Gennaro, Nicolo’, Milano, Eugenio, Santoro, Carmen Rita, Segala, Francesco Vladimiro, Franco, Carlo Felice, Manco Cesari, Giorgia, Frallonardo, Luisa, Guido, Giacomo, Metrangolo, Giuliana, Romita, Greta, Di Gennaro, Francesco, Saracino, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675418/
https://www.ncbi.nlm.nih.gov/pubmed/38005894
http://dx.doi.org/10.3390/v15112217
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author Fiordelisi, Deborah
Poliseno, Mariacristina
De Gennaro, Nicolo’
Milano, Eugenio
Santoro, Carmen Rita
Segala, Francesco Vladimiro
Franco, Carlo Felice
Manco Cesari, Giorgia
Frallonardo, Luisa
Guido, Giacomo
Metrangolo, Giuliana
Romita, Greta
Di Gennaro, Francesco
Saracino, Annalisa
author_facet Fiordelisi, Deborah
Poliseno, Mariacristina
De Gennaro, Nicolo’
Milano, Eugenio
Santoro, Carmen Rita
Segala, Francesco Vladimiro
Franco, Carlo Felice
Manco Cesari, Giorgia
Frallonardo, Luisa
Guido, Giacomo
Metrangolo, Giuliana
Romita, Greta
Di Gennaro, Francesco
Saracino, Annalisa
author_sort Fiordelisi, Deborah
collection PubMed
description Background: The increased vascular risk associated with varicella–zoster virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds for People Living with HIV (PLWH), a group already confronting heightened cardiovascular risk. Methods: Among PLWH who initiated antiretroviral therapy (ART) at our center and have been under our care for >24 months since 1st January 2005, individuals with a history of herpes zoster (HZ) were identified, and their features were compared with those of PLWH with no history of HZ. The prevalence of ischemic events (deep venous thrombosis, stroke, and acute myocardial infarction) was calculated and compared using the chi-square test. An odds ratio (O.R.) and a 95% confidence interval (C.I.) for ischemic events following HZ were evaluated through univariate and multivariate logistic regression. Results: Overall, 45/581 PLWH reported HZ. Ischemic events followed HZ significantly more often than not (13% vs. 5%, p = 0.01). Positive serology for both VZV and HZ correlated with increased ischemic risk (O.R. 4.01, 95% C.I. 1.38–11.6, p = 0.01 and O.R. 3.14, 95% C.I. 1.12–7.68, p = 0.02, respectively), though chronic heart disease demonstrated stronger predictive value in multivariate analysis(O.R. 8.68, 95% C.I. 2.49–29.50, p = 0.001). Conclusions: VZV potentially exacerbates vascular risk in PLWH, particularly in the presence of other predisposing factors. Further research is needed to confirm our data.
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spelling pubmed-106754182023-11-06 Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study Fiordelisi, Deborah Poliseno, Mariacristina De Gennaro, Nicolo’ Milano, Eugenio Santoro, Carmen Rita Segala, Francesco Vladimiro Franco, Carlo Felice Manco Cesari, Giorgia Frallonardo, Luisa Guido, Giacomo Metrangolo, Giuliana Romita, Greta Di Gennaro, Francesco Saracino, Annalisa Viruses Article Background: The increased vascular risk associated with varicella–zoster virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds for People Living with HIV (PLWH), a group already confronting heightened cardiovascular risk. Methods: Among PLWH who initiated antiretroviral therapy (ART) at our center and have been under our care for >24 months since 1st January 2005, individuals with a history of herpes zoster (HZ) were identified, and their features were compared with those of PLWH with no history of HZ. The prevalence of ischemic events (deep venous thrombosis, stroke, and acute myocardial infarction) was calculated and compared using the chi-square test. An odds ratio (O.R.) and a 95% confidence interval (C.I.) for ischemic events following HZ were evaluated through univariate and multivariate logistic regression. Results: Overall, 45/581 PLWH reported HZ. Ischemic events followed HZ significantly more often than not (13% vs. 5%, p = 0.01). Positive serology for both VZV and HZ correlated with increased ischemic risk (O.R. 4.01, 95% C.I. 1.38–11.6, p = 0.01 and O.R. 3.14, 95% C.I. 1.12–7.68, p = 0.02, respectively), though chronic heart disease demonstrated stronger predictive value in multivariate analysis(O.R. 8.68, 95% C.I. 2.49–29.50, p = 0.001). Conclusions: VZV potentially exacerbates vascular risk in PLWH, particularly in the presence of other predisposing factors. Further research is needed to confirm our data. MDPI 2023-11-06 /pmc/articles/PMC10675418/ /pubmed/38005894 http://dx.doi.org/10.3390/v15112217 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fiordelisi, Deborah
Poliseno, Mariacristina
De Gennaro, Nicolo’
Milano, Eugenio
Santoro, Carmen Rita
Segala, Francesco Vladimiro
Franco, Carlo Felice
Manco Cesari, Giorgia
Frallonardo, Luisa
Guido, Giacomo
Metrangolo, Giuliana
Romita, Greta
Di Gennaro, Francesco
Saracino, Annalisa
Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
title Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
title_full Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
title_fullStr Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
title_full_unstemmed Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
title_short Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
title_sort varicella-zoster virus reactivation and increased vascular risk in people living with hiv: data from a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675418/
https://www.ncbi.nlm.nih.gov/pubmed/38005894
http://dx.doi.org/10.3390/v15112217
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