Enolase Inhibitors as Early Lead Therapeutics against Trypanosoma brucei

Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as the lone source of ATP production for the bloodstream form (BSF) parasite in the glucose-rich environment of the host blood. Recently, phosphonate inhibitors of human enolase (ENO), the enzyme responsible for...

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Detalles Bibliográficos
Autores principales: Roster, Colm P., LaVigne, Danielle, Milanes, Jillian E., Knight, Emily, Anderson, Heidi D., Pizarro, Sabrina, Harding, Elijah M., Morris, Meredith T., Yan, Victoria C., Pham, Cong-Dat, Muller, Florian, Kwain, Samuel, Rees, Kerrick C., Dominy, Brian, Whitehead, Daniel C., Uddin, Md Nasir, Millward, Steven W., Morris, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675445/
https://www.ncbi.nlm.nih.gov/pubmed/38003754
http://dx.doi.org/10.3390/pathogens12111290

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