Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138

Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS...

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Autores principales: Zhang, Hui, Ren, Xiaohan, Xu, Haiju, Qi, Huan, Du, Shihua, Huang, Jun, Zhang, Ji, Wang, Jidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675482/
https://www.ncbi.nlm.nih.gov/pubmed/38005394
http://dx.doi.org/10.3390/molecules28227672
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author Zhang, Hui
Ren, Xiaohan
Xu, Haiju
Qi, Huan
Du, Shihua
Huang, Jun
Zhang, Ji
Wang, Jidong
author_facet Zhang, Hui
Ren, Xiaohan
Xu, Haiju
Qi, Huan
Du, Shihua
Huang, Jun
Zhang, Ji
Wang, Jidong
author_sort Zhang, Hui
collection PubMed
description Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.
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spelling pubmed-106754822023-11-20 Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138 Zhang, Hui Ren, Xiaohan Xu, Haiju Qi, Huan Du, Shihua Huang, Jun Zhang, Ji Wang, Jidong Molecules Communication Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively. MDPI 2023-11-20 /pmc/articles/PMC10675482/ /pubmed/38005394 http://dx.doi.org/10.3390/molecules28227672 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Zhang, Hui
Ren, Xiaohan
Xu, Haiju
Qi, Huan
Du, Shihua
Huang, Jun
Zhang, Ji
Wang, Jidong
Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138
title Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138
title_full Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138
title_fullStr Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138
title_full_unstemmed Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138
title_short Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138
title_sort phenopyrrolizins a and b, two novel pyrrolizine alkaloids from marine-derived actinomycetes micromonospora sp. hu138
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675482/
https://www.ncbi.nlm.nih.gov/pubmed/38005394
http://dx.doi.org/10.3390/molecules28227672
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