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Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review

Plukenetia volubilis Linneo or Sacha Inchi (SI), a traditional natural remedy indigenous to Peru and Brazil, has garnered global attention due to its exceptional nutritional composition. Its protective effects against various non-communicable diseases, notably cardiovascular disease (CVD), have beco...

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Autores principales: Abd Rahman, Izzat Zulhilmi, Nor Hisam, Nur Syahidah, Aminuddin, Amilia, Hamid, Adila A., Kumar, Jaya, Ugusman, Azizah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675584/
https://www.ncbi.nlm.nih.gov/pubmed/38004453
http://dx.doi.org/10.3390/ph16111588
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author Abd Rahman, Izzat Zulhilmi
Nor Hisam, Nur Syahidah
Aminuddin, Amilia
Hamid, Adila A.
Kumar, Jaya
Ugusman, Azizah
author_facet Abd Rahman, Izzat Zulhilmi
Nor Hisam, Nur Syahidah
Aminuddin, Amilia
Hamid, Adila A.
Kumar, Jaya
Ugusman, Azizah
author_sort Abd Rahman, Izzat Zulhilmi
collection PubMed
description Plukenetia volubilis Linneo or Sacha Inchi (SI), a traditional natural remedy indigenous to Peru and Brazil, has garnered global attention due to its exceptional nutritional composition. Its protective effects against various non-communicable diseases, notably cardiovascular disease (CVD), have become a subject of interest in recent research. This comprehensive review summarizes the existing evidence from 15 relevant articles concerning the impact of SI on common CVD risk factors, including dyslipidemia, obesity, diabetes, and hypertension. The relevant articles were derived from comprehensive searches on PubMed, Scopus, Google Scholar, and Web of Science using predefined criteria and keywords related to the topic. Overall, SI demonstrated positive effects in attenuating dyslipidemia, obesity, diabetes, and hypertension. The multifaceted mechanisms responsible for the protective effects of SI against these CVD risk factors are primarily attributed to its antioxidative and anti-inflammatory properties. While preclinical studies dominate the current scientific literature on SI, there are limited clinical trials to corroborate these findings. Therefore, future well-designed, large-scale randomized clinical trials are highly recommended to establish the efficacy of SI and determine its optimal dosage, potential drug and food interactions, and practical integration into preventive strategies and dietary interventions for the high-risk populations.
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spelling pubmed-106755842023-11-09 Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review Abd Rahman, Izzat Zulhilmi Nor Hisam, Nur Syahidah Aminuddin, Amilia Hamid, Adila A. Kumar, Jaya Ugusman, Azizah Pharmaceuticals (Basel) Review Plukenetia volubilis Linneo or Sacha Inchi (SI), a traditional natural remedy indigenous to Peru and Brazil, has garnered global attention due to its exceptional nutritional composition. Its protective effects against various non-communicable diseases, notably cardiovascular disease (CVD), have become a subject of interest in recent research. This comprehensive review summarizes the existing evidence from 15 relevant articles concerning the impact of SI on common CVD risk factors, including dyslipidemia, obesity, diabetes, and hypertension. The relevant articles were derived from comprehensive searches on PubMed, Scopus, Google Scholar, and Web of Science using predefined criteria and keywords related to the topic. Overall, SI demonstrated positive effects in attenuating dyslipidemia, obesity, diabetes, and hypertension. The multifaceted mechanisms responsible for the protective effects of SI against these CVD risk factors are primarily attributed to its antioxidative and anti-inflammatory properties. While preclinical studies dominate the current scientific literature on SI, there are limited clinical trials to corroborate these findings. Therefore, future well-designed, large-scale randomized clinical trials are highly recommended to establish the efficacy of SI and determine its optimal dosage, potential drug and food interactions, and practical integration into preventive strategies and dietary interventions for the high-risk populations. MDPI 2023-11-09 /pmc/articles/PMC10675584/ /pubmed/38004453 http://dx.doi.org/10.3390/ph16111588 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abd Rahman, Izzat Zulhilmi
Nor Hisam, Nur Syahidah
Aminuddin, Amilia
Hamid, Adila A.
Kumar, Jaya
Ugusman, Azizah
Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
title Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
title_full Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
title_fullStr Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
title_full_unstemmed Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
title_short Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
title_sort evaluating the potential of plukenetia volubilis linneo (sacha inchi) in alleviating cardiovascular disease risk factors: a mini review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675584/
https://www.ncbi.nlm.nih.gov/pubmed/38004453
http://dx.doi.org/10.3390/ph16111588
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