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The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression

Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, represents one of the most common causes of liver disease, and its incidence is increasing worldwide. It is characterized by a complex etiopathogenesis in which mitochondrial dysfunction exerts a pi...

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Autores principales: Caputo, Valerio, Tarantino, Giovanni, Santini, Silvano Junior, Fracassi, Giovanna, Balsano, Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675587/
https://www.ncbi.nlm.nih.gov/pubmed/38004151
http://dx.doi.org/10.3390/nu15224757
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author Caputo, Valerio
Tarantino, Giovanni
Santini, Silvano Junior
Fracassi, Giovanna
Balsano, Clara
author_facet Caputo, Valerio
Tarantino, Giovanni
Santini, Silvano Junior
Fracassi, Giovanna
Balsano, Clara
author_sort Caputo, Valerio
collection PubMed
description Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, represents one of the most common causes of liver disease, and its incidence is increasing worldwide. It is characterized by a complex etiopathogenesis in which mitochondrial dysfunction exerts a pivotal role together with alteration of lipid metabolism, inflammation, and oxidative stress. Nutrients and bioactive compounds can influence such mechanisms so that changes in diet and lifestyle are regarded as important treatment strategies. Notably, natural compounds can exert their influence through changes of the epigenetic landscape, overall resulting in rewiring of molecular networks involved in cell and tissue homeostasis. Considering such information, the present review aims at providing evidence of epigenetic modifications occurring at mitochondria in response to natural and bioactive compounds in the context of liver (dys)function. For this purpose, recent studies reporting effects of compounds on mitochondria in the context of NAFLD/MASLD, as well as research showing alteration of DNA methylation and non-coding RNAs-related circuits occurring at liver mitochondria, will be illustrated. Overall, the present review will highlight the importance of understanding the bioactive compounds-dependent epigenetic modulation of mitochondria for improving the knowledge of MASLD and identifying biomarkers to be employed for effective preventative strategies or treatment protocols.
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spelling pubmed-106755872023-11-12 The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression Caputo, Valerio Tarantino, Giovanni Santini, Silvano Junior Fracassi, Giovanna Balsano, Clara Nutrients Review Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, represents one of the most common causes of liver disease, and its incidence is increasing worldwide. It is characterized by a complex etiopathogenesis in which mitochondrial dysfunction exerts a pivotal role together with alteration of lipid metabolism, inflammation, and oxidative stress. Nutrients and bioactive compounds can influence such mechanisms so that changes in diet and lifestyle are regarded as important treatment strategies. Notably, natural compounds can exert their influence through changes of the epigenetic landscape, overall resulting in rewiring of molecular networks involved in cell and tissue homeostasis. Considering such information, the present review aims at providing evidence of epigenetic modifications occurring at mitochondria in response to natural and bioactive compounds in the context of liver (dys)function. For this purpose, recent studies reporting effects of compounds on mitochondria in the context of NAFLD/MASLD, as well as research showing alteration of DNA methylation and non-coding RNAs-related circuits occurring at liver mitochondria, will be illustrated. Overall, the present review will highlight the importance of understanding the bioactive compounds-dependent epigenetic modulation of mitochondria for improving the knowledge of MASLD and identifying biomarkers to be employed for effective preventative strategies or treatment protocols. MDPI 2023-11-12 /pmc/articles/PMC10675587/ /pubmed/38004151 http://dx.doi.org/10.3390/nu15224757 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Caputo, Valerio
Tarantino, Giovanni
Santini, Silvano Junior
Fracassi, Giovanna
Balsano, Clara
The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression
title The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression
title_full The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression
title_fullStr The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression
title_full_unstemmed The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression
title_short The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression
title_sort role of epigenetic control of mitochondrial (dys)function in masld onset and progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675587/
https://www.ncbi.nlm.nih.gov/pubmed/38004151
http://dx.doi.org/10.3390/nu15224757
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