Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma

We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthrit...

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Autores principales: Da Silva, Léa, Klopfenstein, Timothée, Gendrin, Vincent, Clouet, Julien, Toko, Lynda, Richier, Quentin, Leriche, Thomas, Nicolas, Raoul, Queijo, Alexis, Sreiri, Nour, Lacombe, Karine, Zayet, Souheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675708/
https://www.ncbi.nlm.nih.gov/pubmed/38005897
http://dx.doi.org/10.3390/v15112220
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author Da Silva, Léa
Klopfenstein, Timothée
Gendrin, Vincent
Clouet, Julien
Toko, Lynda
Richier, Quentin
Leriche, Thomas
Nicolas, Raoul
Queijo, Alexis
Sreiri, Nour
Lacombe, Karine
Zayet, Souheil
author_facet Da Silva, Léa
Klopfenstein, Timothée
Gendrin, Vincent
Clouet, Julien
Toko, Lynda
Richier, Quentin
Leriche, Thomas
Nicolas, Raoul
Queijo, Alexis
Sreiri, Nour
Lacombe, Karine
Zayet, Souheil
author_sort Da Silva, Léa
collection PubMed
description We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthritis. Real-time reverse transcription-polymerase chain reaction on a nasopharyngeal swab specimen was negative in all patients. SARS-CoV-2 infection was confirmed from bronchoalveolar lavage fluid. A high titer of post-vaccine COVID-19 convalescent plasma was administered with complete recovery in all patients.
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spelling pubmed-106757082023-11-07 Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma Da Silva, Léa Klopfenstein, Timothée Gendrin, Vincent Clouet, Julien Toko, Lynda Richier, Quentin Leriche, Thomas Nicolas, Raoul Queijo, Alexis Sreiri, Nour Lacombe, Karine Zayet, Souheil Viruses Case Report We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthritis. Real-time reverse transcription-polymerase chain reaction on a nasopharyngeal swab specimen was negative in all patients. SARS-CoV-2 infection was confirmed from bronchoalveolar lavage fluid. A high titer of post-vaccine COVID-19 convalescent plasma was administered with complete recovery in all patients. MDPI 2023-11-07 /pmc/articles/PMC10675708/ /pubmed/38005897 http://dx.doi.org/10.3390/v15112220 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Da Silva, Léa
Klopfenstein, Timothée
Gendrin, Vincent
Clouet, Julien
Toko, Lynda
Richier, Quentin
Leriche, Thomas
Nicolas, Raoul
Queijo, Alexis
Sreiri, Nour
Lacombe, Karine
Zayet, Souheil
Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
title Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
title_full Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
title_fullStr Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
title_full_unstemmed Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
title_short Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
title_sort prolonged sars-cov-2 infection in patients receiving anti-cd20 monoclonal antibodies: a diagnostic challenged by negative nasopharyngeal rt-pcr and successful treatment with covid-19 high-titer convalescent plasma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675708/
https://www.ncbi.nlm.nih.gov/pubmed/38005897
http://dx.doi.org/10.3390/v15112220
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