Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of SARM1, a protein that is also expressed in C. elegans (ceSARM/ceTIR-1). We hypothesized that differences in SARM between species might exist...

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Detalles Bibliográficos
Autores principales: Khazma, Tami, Grossman, Atira, Guez-Haddad, Julia, Feng, Chengye, Dabas, Hadas, Sain, Radhika, Weitman, Michal, Zalk, Ran, Isupov, Michail N., Hammarlund, Marc, Hons, Michael, Opatowsky, Yarden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675840/
https://www.ncbi.nlm.nih.gov/pubmed/37635352
http://dx.doi.org/10.1016/j.celrep.2023.113026

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