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The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database

BACKGROUND: Ascorbic acid or vitamin C has antioxidant and anti-inflammatory properties that may impact markers of inflammation like C-reactive protein (CRP). However, studies specifically on vitamin C and high-sensitivity CRP (hs-CRP) have been scarce. METHODS: We conducted a cross-sectional analys...

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Detalles Bibliográficos
Autores principales: Ding, Ning, Zeng, Zhao, Luo, Ju, Li, Keng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675847/
https://www.ncbi.nlm.nih.gov/pubmed/38024382
http://dx.doi.org/10.3389/fnut.2023.1290749
Descripción
Sumario:BACKGROUND: Ascorbic acid or vitamin C has antioxidant and anti-inflammatory properties that may impact markers of inflammation like C-reactive protein (CRP). However, studies specifically on vitamin C and high-sensitivity CRP (hs-CRP) have been scarce. METHODS: We conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey 2017–2018 dataset including 5,380 U.S. adults aged ≥20 years. Multiple regression models examined the relationship between plasma vitamin C and serum hs-CRP while adjusting for potential confounders. Stratified analyses and curve fitting assessed effect modification and nonlinearity. RESULTS: An inverse association was found between plasma vitamin C and serum hs-CRP overall (β = −0.025, 95% CI: −0.033 to −0.017, p < 0.00001) and in subgroups except for the “other Hispanic” subgroup in model II (β = −0.009, 95% CI: (−0.040, 0.023), p = 0.5885). The relationship was nonlinear, with the greatest hs-CRP reduction observed up to a plasma vitamin C level of 53.1 μmol/L. CONCLUSION: The results showed a non-linear negative correlation between vitamin C levels and hs-CRP in adults. These results suggest vitamin C intake may reduce inflammation and cardiovascular risk, but only up to 53.1 μmol/L plasma vitamin C.