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Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors

PURPOSE: Postamputation neuropathic pain is a common disease in patients with malignant tumor amputation, seriously affecting amputees’ quality of life and mental health. The objective of this study was to identify independent risk factors for phantom limb pain in patients with tumor amputation and...

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Autores principales: Huo, Xiulin, Huang, Peiying, Di, Hexuan, Ma, Tianxiao, Jiang, Sufang, Yao, Jie, Huang, Lining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676115/
https://www.ncbi.nlm.nih.gov/pubmed/38026454
http://dx.doi.org/10.2147/JPR.S433996
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author Huo, Xiulin
Huang, Peiying
Di, Hexuan
Ma, Tianxiao
Jiang, Sufang
Yao, Jie
Huang, Lining
author_facet Huo, Xiulin
Huang, Peiying
Di, Hexuan
Ma, Tianxiao
Jiang, Sufang
Yao, Jie
Huang, Lining
author_sort Huo, Xiulin
collection PubMed
description PURPOSE: Postamputation neuropathic pain is a common disease in patients with malignant tumor amputation, seriously affecting amputees’ quality of life and mental health. The objective of this study was to identify independent risk factors for phantom limb pain in patients with tumor amputation and to construct a risk prediction model. METHODS: Patients who underwent amputation due to malignant tumors from 2013 to 2023 were retrospectively analyzed and divided into phantom limb pain group and non-phantom limb pain group. To determine which preoperative factors would affect the occurrence of phantom limb pain, we searched for candidate factors by univariate analysis and used multivariate logistic regression analysis to identify independent factors and construct a predictive model. The receiver operating characteristic curve (ROC) was drawn to further evaluate the accuracy of the prediction model in evaluating the phantom limb pain after amputation of bone and soft tissue tumors. RESULTS: Multivariate analysis showed that age (OR, 1.054; 95% CI, 1.027 to 1.080), preoperative pain (OR, 5.773; 95% CI, 2.362 to 14.104), number of surgeries (OR, 3.425; 95% CI, 1.505 to 7.795), amputation site (OR, 5.848; 95% CI, 1.837 to 18.620), amputation level (OR, 8.031; 95% CI, 2.491 to 25.888) were independent risk factors for phantom limb pain for bone and soft tissue tumors. The the area under the curve (AUC) of this model was 0.834. CONCLUSION: Risk factors for postoperative phantom limb pain were the site of amputation, proximal amputation, preoperative pain, multiple amputations, and older age. These factors will help surgeons to individualize and stratify phantom limb pain and help patients with risk counseling. In particular, an informed clinical decision targeting those modifiable factors can be considered when needed.
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spelling pubmed-106761152023-11-21 Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors Huo, Xiulin Huang, Peiying Di, Hexuan Ma, Tianxiao Jiang, Sufang Yao, Jie Huang, Lining J Pain Res Original Research PURPOSE: Postamputation neuropathic pain is a common disease in patients with malignant tumor amputation, seriously affecting amputees’ quality of life and mental health. The objective of this study was to identify independent risk factors for phantom limb pain in patients with tumor amputation and to construct a risk prediction model. METHODS: Patients who underwent amputation due to malignant tumors from 2013 to 2023 were retrospectively analyzed and divided into phantom limb pain group and non-phantom limb pain group. To determine which preoperative factors would affect the occurrence of phantom limb pain, we searched for candidate factors by univariate analysis and used multivariate logistic regression analysis to identify independent factors and construct a predictive model. The receiver operating characteristic curve (ROC) was drawn to further evaluate the accuracy of the prediction model in evaluating the phantom limb pain after amputation of bone and soft tissue tumors. RESULTS: Multivariate analysis showed that age (OR, 1.054; 95% CI, 1.027 to 1.080), preoperative pain (OR, 5.773; 95% CI, 2.362 to 14.104), number of surgeries (OR, 3.425; 95% CI, 1.505 to 7.795), amputation site (OR, 5.848; 95% CI, 1.837 to 18.620), amputation level (OR, 8.031; 95% CI, 2.491 to 25.888) were independent risk factors for phantom limb pain for bone and soft tissue tumors. The the area under the curve (AUC) of this model was 0.834. CONCLUSION: Risk factors for postoperative phantom limb pain were the site of amputation, proximal amputation, preoperative pain, multiple amputations, and older age. These factors will help surgeons to individualize and stratify phantom limb pain and help patients with risk counseling. In particular, an informed clinical decision targeting those modifiable factors can be considered when needed. Dove 2023-11-21 /pmc/articles/PMC10676115/ /pubmed/38026454 http://dx.doi.org/10.2147/JPR.S433996 Text en © 2023 Huo et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Huo, Xiulin
Huang, Peiying
Di, Hexuan
Ma, Tianxiao
Jiang, Sufang
Yao, Jie
Huang, Lining
Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors
title Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors
title_full Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors
title_fullStr Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors
title_full_unstemmed Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors
title_short Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors
title_sort risk factors analysis of phantom limb pain in amputees with malignant tumors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676115/
https://www.ncbi.nlm.nih.gov/pubmed/38026454
http://dx.doi.org/10.2147/JPR.S433996
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