Large Pericardial Cyst Mimicking Recurrent Unilateral Pleural Effusion on CT Scan: A Case Report and Literature Review

Pericardial cysts are an uncommon, benign condition that can manifest with diverse clinical symptoms influenced by their size and position within the body. Detecting pericardial cysts typically relies on imaging studies for a conclusive diagnosis. Surgical removal remains the definitive treatment approach for addressing pericardial cysts. This case report presents the clinical course of a 56-year-old female with a known case of asthma, and rheumatoid arthritis (RA) which exhibited recurrent symptoms such as shortness of breath and cough with recurrent pleural effusion to be investigated for suspected empyema, encysted effusion, TB, or malignancy, leading to diagnostic challenges. Through a combination of reviewing the case's clinical history, imaging modalities, and diagnostic procedures, including serial computed tomography (CT) and x-rays, the accurate diagnosis of a pericardial cyst sized 4.4 cm x 10.5 cm x 6.2 cm was achieved. In this specific case, recurrent percutaneous pleural aspirations were attempted as a treatment approach for three years. However, despite these efforts, this method proved unsuccessful in effectively managing the patient's condition. Using minimally invasive techniques, video-assisted thoracoscopic surgery (VATS) proved valuable in providing effective diagnostic and therapeutic options with reduced invasiveness. Timely diagnosis, proper monitoring, and patient education contributed to the patient's overall recovery.