Extracellular vesicle-induced cyclic AMP signaling

Second messenger signaling is required for cellular processes. We previously reported that extracellular vesicles (EVs) from stimulated cultured endothelial cells contain the biochemical second messenger, cAMP. In the current study, we sought to determine whether cAMP-enriched EVs induce second mess...

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Autores principales: Bhadra, Aritra, Scruggs, April K., Leavesley, Silas J., Annamdevula, Naga, George, April H., Britain, Andrea L., Francis, Christopher M., Knighten, Jennifer M., Rich, Thomas C., Bauer, Natalie N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676271/
https://www.ncbi.nlm.nih.gov/pubmed/35504529
http://dx.doi.org/10.1016/j.cellsig.2022.110348
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author Bhadra, Aritra
Scruggs, April K.
Leavesley, Silas J.
Annamdevula, Naga
George, April H.
Britain, Andrea L.
Francis, Christopher M.
Knighten, Jennifer M.
Rich, Thomas C.
Bauer, Natalie N.
author_facet Bhadra, Aritra
Scruggs, April K.
Leavesley, Silas J.
Annamdevula, Naga
George, April H.
Britain, Andrea L.
Francis, Christopher M.
Knighten, Jennifer M.
Rich, Thomas C.
Bauer, Natalie N.
author_sort Bhadra, Aritra
collection PubMed
description Second messenger signaling is required for cellular processes. We previously reported that extracellular vesicles (EVs) from stimulated cultured endothelial cells contain the biochemical second messenger, cAMP. In the current study, we sought to determine whether cAMP-enriched EVs induce second messenger signaling pathways in naïve recipient cells. Our results indicate that cAMP-enriched EVs increase cAMP content sufficient to stimulate PKA activity. The implications of our work are that EVs represent a novel intercellular mechanism for second messenger, specifically cAMP, signaling.
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spelling pubmed-106762712023-11-25 Extracellular vesicle-induced cyclic AMP signaling Bhadra, Aritra Scruggs, April K. Leavesley, Silas J. Annamdevula, Naga George, April H. Britain, Andrea L. Francis, Christopher M. Knighten, Jennifer M. Rich, Thomas C. Bauer, Natalie N. Cell Signal Article Second messenger signaling is required for cellular processes. We previously reported that extracellular vesicles (EVs) from stimulated cultured endothelial cells contain the biochemical second messenger, cAMP. In the current study, we sought to determine whether cAMP-enriched EVs induce second messenger signaling pathways in naïve recipient cells. Our results indicate that cAMP-enriched EVs increase cAMP content sufficient to stimulate PKA activity. The implications of our work are that EVs represent a novel intercellular mechanism for second messenger, specifically cAMP, signaling. 2022-07 2022-04-30 /pmc/articles/PMC10676271/ /pubmed/35504529 http://dx.doi.org/10.1016/j.cellsig.2022.110348 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Bhadra, Aritra
Scruggs, April K.
Leavesley, Silas J.
Annamdevula, Naga
George, April H.
Britain, Andrea L.
Francis, Christopher M.
Knighten, Jennifer M.
Rich, Thomas C.
Bauer, Natalie N.
Extracellular vesicle-induced cyclic AMP signaling
title Extracellular vesicle-induced cyclic AMP signaling
title_full Extracellular vesicle-induced cyclic AMP signaling
title_fullStr Extracellular vesicle-induced cyclic AMP signaling
title_full_unstemmed Extracellular vesicle-induced cyclic AMP signaling
title_short Extracellular vesicle-induced cyclic AMP signaling
title_sort extracellular vesicle-induced cyclic amp signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676271/
https://www.ncbi.nlm.nih.gov/pubmed/35504529
http://dx.doi.org/10.1016/j.cellsig.2022.110348
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