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Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors

BACKGROUND: It is well known that laboratory markers could help in identifying risk factors of severe illness and predicting outcomes of diseases. Here, we performed a retrospective modeling study of severity and mortality predictors of hematological and biochemical laboratory parameters in Iranian...

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Autores principales: Alizad, Ghazaleh, Ayatollahi, Ali Asghar, Shariati Samani, Armin, Samadizadeh, Saeed, Aghcheli, Bahman, Rajabi, Abdolhalim, Nakstad, Britt, Tahamtan, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676280/
https://www.ncbi.nlm.nih.gov/pubmed/38027038
http://dx.doi.org/10.1155/2023/7753631
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author Alizad, Ghazaleh
Ayatollahi, Ali Asghar
Shariati Samani, Armin
Samadizadeh, Saeed
Aghcheli, Bahman
Rajabi, Abdolhalim
Nakstad, Britt
Tahamtan, Alireza
author_facet Alizad, Ghazaleh
Ayatollahi, Ali Asghar
Shariati Samani, Armin
Samadizadeh, Saeed
Aghcheli, Bahman
Rajabi, Abdolhalim
Nakstad, Britt
Tahamtan, Alireza
author_sort Alizad, Ghazaleh
collection PubMed
description BACKGROUND: It is well known that laboratory markers could help in identifying risk factors of severe illness and predicting outcomes of diseases. Here, we performed a retrospective modeling study of severity and mortality predictors of hematological and biochemical laboratory parameters in Iranian COVID-19 patients. METHODS: Data were obtained retrospectively from medical records of 564 confirmed Iranian COVID-19 cases. According to the disease severity, the patients were categorized into two groups (severe or nonsevere), and based on the outcome of the disease, patients were divided into two groups (recovered or deceased). Demographic and laboratory data were compared between groups, and statistical analyses were performed to define predictors of disease severity and mortality in the patients. RESULTS: The study identified a panel of hematological and biochemical markers associated with the severe outcome of COVID-19 and constructed different predictive models for severity and mortality. The disease severity and mortality rate were significantly higher in elderly inpatients, whereas gender was not a determining factor of the clinical outcome. Age-adjusted white blood cells (WBC), platelet cells (PLT), neutrophil-to-lymphocyte ratio (NLR), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), erythrocyte sedimentation rate (ESR), mean corpuscular hemoglobin (MCHC), blood urea nitrogen (BUN), and creatinine (Cr) also showed high accuracy in predicting severe cases at the time of hospitalization, and logistic regression analysis suggested grouped hematological parameters (age, WBC, NLR, PLT, HGB, and international normalized ratio (INR)) and biochemical markers (age, BUN, and lactate dehydrogenase (LDH)) as the best models of combined laboratory predictors for severity and mortality. CONCLUSION: The findings suggest that a panel of several routine laboratory parameters recorded on admission could be helpful for clinicians to predict and evaluate the risk of disease severity and mortality in COVID-19 patients.
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spelling pubmed-106762802023-11-18 Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors Alizad, Ghazaleh Ayatollahi, Ali Asghar Shariati Samani, Armin Samadizadeh, Saeed Aghcheli, Bahman Rajabi, Abdolhalim Nakstad, Britt Tahamtan, Alireza Biomed Res Int Research Article BACKGROUND: It is well known that laboratory markers could help in identifying risk factors of severe illness and predicting outcomes of diseases. Here, we performed a retrospective modeling study of severity and mortality predictors of hematological and biochemical laboratory parameters in Iranian COVID-19 patients. METHODS: Data were obtained retrospectively from medical records of 564 confirmed Iranian COVID-19 cases. According to the disease severity, the patients were categorized into two groups (severe or nonsevere), and based on the outcome of the disease, patients were divided into two groups (recovered or deceased). Demographic and laboratory data were compared between groups, and statistical analyses were performed to define predictors of disease severity and mortality in the patients. RESULTS: The study identified a panel of hematological and biochemical markers associated with the severe outcome of COVID-19 and constructed different predictive models for severity and mortality. The disease severity and mortality rate were significantly higher in elderly inpatients, whereas gender was not a determining factor of the clinical outcome. Age-adjusted white blood cells (WBC), platelet cells (PLT), neutrophil-to-lymphocyte ratio (NLR), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), erythrocyte sedimentation rate (ESR), mean corpuscular hemoglobin (MCHC), blood urea nitrogen (BUN), and creatinine (Cr) also showed high accuracy in predicting severe cases at the time of hospitalization, and logistic regression analysis suggested grouped hematological parameters (age, WBC, NLR, PLT, HGB, and international normalized ratio (INR)) and biochemical markers (age, BUN, and lactate dehydrogenase (LDH)) as the best models of combined laboratory predictors for severity and mortality. CONCLUSION: The findings suggest that a panel of several routine laboratory parameters recorded on admission could be helpful for clinicians to predict and evaluate the risk of disease severity and mortality in COVID-19 patients. Hindawi 2023-11-18 /pmc/articles/PMC10676280/ /pubmed/38027038 http://dx.doi.org/10.1155/2023/7753631 Text en Copyright © 2023 Ghazaleh Alizad et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alizad, Ghazaleh
Ayatollahi, Ali Asghar
Shariati Samani, Armin
Samadizadeh, Saeed
Aghcheli, Bahman
Rajabi, Abdolhalim
Nakstad, Britt
Tahamtan, Alireza
Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors
title Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors
title_full Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors
title_fullStr Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors
title_full_unstemmed Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors
title_short Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors
title_sort hematological and biochemical laboratory parameters in covid-19 patients: a retrospective modeling study of severity and mortality predictors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676280/
https://www.ncbi.nlm.nih.gov/pubmed/38027038
http://dx.doi.org/10.1155/2023/7753631
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