Hepatic β-arrestins: potential roles in liver health and disease

Β-arrestins are intracellular scaffolding proteins that have multifaceted roles in different types of disorders. In this review article, we gave a summary about the discovery, characterization and classification of these proteins and their intracellular functions. Moreover, this review article focus...

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Detalles Bibliográficos
Autores principales: Eissa, Alzahraa Muhammad, Hassanin, Mohamed H., Ibrahim, Islam A. A. E. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676313/
https://www.ncbi.nlm.nih.gov/pubmed/37843713
http://dx.doi.org/10.1007/s11033-023-08898-0
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author Eissa, Alzahraa Muhammad
Hassanin, Mohamed H.
Ibrahim, Islam A. A. E. H.
author_facet Eissa, Alzahraa Muhammad
Hassanin, Mohamed H.
Ibrahim, Islam A. A. E. H.
author_sort Eissa, Alzahraa Muhammad
collection PubMed
description Β-arrestins are intracellular scaffolding proteins that have multifaceted roles in different types of disorders. In this review article, we gave a summary about the discovery, characterization and classification of these proteins and their intracellular functions. Moreover, this review article focused on the hepatic expression of β-arrestins and their hepatocellular distribution and function in each liver cell type. Also, we showed that β-arrestins are key regulators of distinct types of hepatic disorders. On the other hand, we addressed some important points that have never been studied before regarding the role of β-arrestins in certain types of hepatic disorders which needs more research efforts to cover.
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spelling pubmed-106763132023-10-16 Hepatic β-arrestins: potential roles in liver health and disease Eissa, Alzahraa Muhammad Hassanin, Mohamed H. Ibrahim, Islam A. A. E. H. Mol Biol Rep Review Β-arrestins are intracellular scaffolding proteins that have multifaceted roles in different types of disorders. In this review article, we gave a summary about the discovery, characterization and classification of these proteins and their intracellular functions. Moreover, this review article focused on the hepatic expression of β-arrestins and their hepatocellular distribution and function in each liver cell type. Also, we showed that β-arrestins are key regulators of distinct types of hepatic disorders. On the other hand, we addressed some important points that have never been studied before regarding the role of β-arrestins in certain types of hepatic disorders which needs more research efforts to cover. Springer Netherlands 2023-10-16 2023 /pmc/articles/PMC10676313/ /pubmed/37843713 http://dx.doi.org/10.1007/s11033-023-08898-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Eissa, Alzahraa Muhammad
Hassanin, Mohamed H.
Ibrahim, Islam A. A. E. H.
Hepatic β-arrestins: potential roles in liver health and disease
title Hepatic β-arrestins: potential roles in liver health and disease
title_full Hepatic β-arrestins: potential roles in liver health and disease
title_fullStr Hepatic β-arrestins: potential roles in liver health and disease
title_full_unstemmed Hepatic β-arrestins: potential roles in liver health and disease
title_short Hepatic β-arrestins: potential roles in liver health and disease
title_sort hepatic β-arrestins: potential roles in liver health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676313/
https://www.ncbi.nlm.nih.gov/pubmed/37843713
http://dx.doi.org/10.1007/s11033-023-08898-0
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