Functional implications of paralog genes in polyglutamine spinocerebellar ataxias

Polyglutamine (polyQ) spinocerebellar ataxias (SCAs) comprise a group of autosomal dominant neurodegenerative disorders caused by (CAG/CAA)(n) expansions. The elongated stretches of adjacent glutamines alter the conformation of the native proteins inducing neurotoxicity, and subsequent motor and neu...

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Detalles Bibliográficos
Autores principales: Felício, Daniela, du Mérac, Tanguy Rubat, Amorim, António, Martins, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676324/
https://www.ncbi.nlm.nih.gov/pubmed/37845370
http://dx.doi.org/10.1007/s00439-023-02607-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676324/
https://www.ncbi.nlm.nih.gov/pubmed/37845370
http://dx.doi.org/10.1007/s00439-023-02607-4

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