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Effect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults

BACKGROUND AND OBJECTIVES: This study was conducted to investigate the effect of high-fat meals on the pharmacokinetics (PK) and safety profile of SAF-189s, a novel ALK/ROS1 inhibitor. METHODS: This was a single-center, phase I, open-label, crossover study in which healthy adults (≥18 years) were ra...

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Detalles Bibliográficos
Autores principales:	Qin, Huiling, Tan, Yan, Diao, Lei, Hui, Ai-Min, Wu, Zhuli, Zhou, Yongchun, Sun, Juan, Xiang, Xiao, Qiu, Jingjun, Hu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676332/ https://www.ncbi.nlm.nih.gov/pubmed/37934354 http://dx.doi.org/10.1007/s40268-023-00446-2

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