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Diversity of cortical activity changes beyond depression during Spreading Depolarizations

Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in electrocorticographic activity, especially in the...

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Autores principales: Nasretdinov, Azat, Vinokurova, Daria, Lemale, Coline L., Burkhanova-Zakirova, Gulshat, Chernova, Ksenia, Makarova, Julia, Herreras, Oscar, Dreier, Jens P., Khazipov, Roustem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676372/
https://www.ncbi.nlm.nih.gov/pubmed/38007508
http://dx.doi.org/10.1038/s41467-023-43509-3
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author Nasretdinov, Azat
Vinokurova, Daria
Lemale, Coline L.
Burkhanova-Zakirova, Gulshat
Chernova, Ksenia
Makarova, Julia
Herreras, Oscar
Dreier, Jens P.
Khazipov, Roustem
author_facet Nasretdinov, Azat
Vinokurova, Daria
Lemale, Coline L.
Burkhanova-Zakirova, Gulshat
Chernova, Ksenia
Makarova, Julia
Herreras, Oscar
Dreier, Jens P.
Khazipov, Roustem
author_sort Nasretdinov, Azat
collection PubMed
description Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in electrocorticographic activity, especially in the delta frequency band. In rats, depression of activity was characteristic of high-potassium-induced full SDs, whereas partial superficial SDs caused either little change or a boom of activity at the cortical vertex, supported by volume conduction of signals from spared delta generators in the deep cortical layers. Partial SDs also caused moderate neuronal depolarization and sustained excitation, organized in gamma oscillations in a narrow sub-SD zone. Thus, our study challenges the concept of homology between spreading depolarization and spreading depression by showing that SDs produce variable, from depression to booming, changes in activity at the cortical surface and in different cortical layers depending on the depth of SD penetration.
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spelling pubmed-106763722023-11-25 Diversity of cortical activity changes beyond depression during Spreading Depolarizations Nasretdinov, Azat Vinokurova, Daria Lemale, Coline L. Burkhanova-Zakirova, Gulshat Chernova, Ksenia Makarova, Julia Herreras, Oscar Dreier, Jens P. Khazipov, Roustem Nat Commun Article Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in electrocorticographic activity, especially in the delta frequency band. In rats, depression of activity was characteristic of high-potassium-induced full SDs, whereas partial superficial SDs caused either little change or a boom of activity at the cortical vertex, supported by volume conduction of signals from spared delta generators in the deep cortical layers. Partial SDs also caused moderate neuronal depolarization and sustained excitation, organized in gamma oscillations in a narrow sub-SD zone. Thus, our study challenges the concept of homology between spreading depolarization and spreading depression by showing that SDs produce variable, from depression to booming, changes in activity at the cortical surface and in different cortical layers depending on the depth of SD penetration. Nature Publishing Group UK 2023-11-25 /pmc/articles/PMC10676372/ /pubmed/38007508 http://dx.doi.org/10.1038/s41467-023-43509-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nasretdinov, Azat
Vinokurova, Daria
Lemale, Coline L.
Burkhanova-Zakirova, Gulshat
Chernova, Ksenia
Makarova, Julia
Herreras, Oscar
Dreier, Jens P.
Khazipov, Roustem
Diversity of cortical activity changes beyond depression during Spreading Depolarizations
title Diversity of cortical activity changes beyond depression during Spreading Depolarizations
title_full Diversity of cortical activity changes beyond depression during Spreading Depolarizations
title_fullStr Diversity of cortical activity changes beyond depression during Spreading Depolarizations
title_full_unstemmed Diversity of cortical activity changes beyond depression during Spreading Depolarizations
title_short Diversity of cortical activity changes beyond depression during Spreading Depolarizations
title_sort diversity of cortical activity changes beyond depression during spreading depolarizations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676372/
https://www.ncbi.nlm.nih.gov/pubmed/38007508
http://dx.doi.org/10.1038/s41467-023-43509-3
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