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The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review

BACKGROUND: Multiple myeloma (MM) is a rare cancer, and information on its pathological condition and serum element levels is lacking. In this pilot study, we examined serum element concentrations in Japanese patients with MM by a comprehensive multi-element analysis. METHODS: This is a case-control...

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Autores principales: Yamamoto, Yuko, Kondo, Masahiro, Hotta, Yuji, Tashiro, Yuusuke, Sanagawa, Akimasa, Kataoka, Tomoya, Furukawa-Hibi, Yoko, Ri, Masaki, Komatsu, Hirokazu, Iida, Shinsuke, Kimura, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676486/
https://www.ncbi.nlm.nih.gov/pubmed/37505784
http://dx.doi.org/10.31557/APJCP.2023.24.7.2493
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author Yamamoto, Yuko
Kondo, Masahiro
Hotta, Yuji
Tashiro, Yuusuke
Sanagawa, Akimasa
Kataoka, Tomoya
Furukawa-Hibi, Yoko
Ri, Masaki
Komatsu, Hirokazu
Iida, Shinsuke
Kimura, Kazunori
author_facet Yamamoto, Yuko
Kondo, Masahiro
Hotta, Yuji
Tashiro, Yuusuke
Sanagawa, Akimasa
Kataoka, Tomoya
Furukawa-Hibi, Yoko
Ri, Masaki
Komatsu, Hirokazu
Iida, Shinsuke
Kimura, Kazunori
author_sort Yamamoto, Yuko
collection PubMed
description BACKGROUND: Multiple myeloma (MM) is a rare cancer, and information on its pathological condition and serum element levels is lacking. In this pilot study, we examined serum element concentrations in Japanese patients with MM by a comprehensive multi-element analysis. METHODS: This is a case-control study of 12 Japanese patients diagnosed with MM at the Nagoya City University Hospital between 2008 and 2013. Blood samples were taken, at the initial diagnosis and at relapse. The serum concentrations of 12 elements were analyzed by inductively coupled plasma mass spectrometry and compared between MM patients and non-MM volunteers. We also analyzed the correlation between serum element concentrations and laboratory values related to disease status and tumor volume of MM. RESULTS: We found that serum chromium (Cr), copper (Cu), molybdenum (Mo), and barium (Ba) concentrations were significantly increased in MM patients. Ba was significantly increased in MM patients, suggesting an association with bone lesions. There was no consistent trend between these elements and existing indices related to MM tumor volume and disease status. CONCLUSIONS: Although this is a pilot study, serum Cr, Cu, Mo, and Ba concentrations were found to be significantly elevated in MM patients. Further studies with large sample sizes are needed, since the changes in serum concentrations of these elements may reflect the pathological condition of MM.
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spelling pubmed-106764862023-03-01 The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review Yamamoto, Yuko Kondo, Masahiro Hotta, Yuji Tashiro, Yuusuke Sanagawa, Akimasa Kataoka, Tomoya Furukawa-Hibi, Yoko Ri, Masaki Komatsu, Hirokazu Iida, Shinsuke Kimura, Kazunori Asian Pac J Cancer Prev Research Article BACKGROUND: Multiple myeloma (MM) is a rare cancer, and information on its pathological condition and serum element levels is lacking. In this pilot study, we examined serum element concentrations in Japanese patients with MM by a comprehensive multi-element analysis. METHODS: This is a case-control study of 12 Japanese patients diagnosed with MM at the Nagoya City University Hospital between 2008 and 2013. Blood samples were taken, at the initial diagnosis and at relapse. The serum concentrations of 12 elements were analyzed by inductively coupled plasma mass spectrometry and compared between MM patients and non-MM volunteers. We also analyzed the correlation between serum element concentrations and laboratory values related to disease status and tumor volume of MM. RESULTS: We found that serum chromium (Cr), copper (Cu), molybdenum (Mo), and barium (Ba) concentrations were significantly increased in MM patients. Ba was significantly increased in MM patients, suggesting an association with bone lesions. There was no consistent trend between these elements and existing indices related to MM tumor volume and disease status. CONCLUSIONS: Although this is a pilot study, serum Cr, Cu, Mo, and Ba concentrations were found to be significantly elevated in MM patients. Further studies with large sample sizes are needed, since the changes in serum concentrations of these elements may reflect the pathological condition of MM. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10676486/ /pubmed/37505784 http://dx.doi.org/10.31557/APJCP.2023.24.7.2493 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Yamamoto, Yuko
Kondo, Masahiro
Hotta, Yuji
Tashiro, Yuusuke
Sanagawa, Akimasa
Kataoka, Tomoya
Furukawa-Hibi, Yoko
Ri, Masaki
Komatsu, Hirokazu
Iida, Shinsuke
Kimura, Kazunori
The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review
title The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review
title_full The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review
title_fullStr The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review
title_full_unstemmed The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review
title_short The Relationship between Changes in Serum Element Concentrations and Pathological Condition and Disease Status in Japanese Multiple Myeloma Patients: A Pilot Study and Literature Review
title_sort relationship between changes in serum element concentrations and pathological condition and disease status in japanese multiple myeloma patients: a pilot study and literature review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676486/
https://www.ncbi.nlm.nih.gov/pubmed/37505784
http://dx.doi.org/10.31557/APJCP.2023.24.7.2493
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