The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines

This study aimed to find out the mechanism of cytotoxic effects of galls of Quercus Brantii on A375 and SK-MEL-3 melanoma and AGO-1522 normal human fibroblast cell lines for the first time. Therefore, cell viability and cytotoxic activities were evaluated. Furthermore, ROS formation, lipid peroxidat...

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Autores principales: Yousefsani, Bahareh Sadat, Mohajer, Kamyar, Qobadi, Ali, Aghazadeh, Elahe, Shirani, Kobra, Pourahmad, Jalal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676489/
https://www.ncbi.nlm.nih.gov/pubmed/37505770
http://dx.doi.org/10.31557/APJCP.2023.24.7.2383
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author Yousefsani, Bahareh Sadat
Mohajer, Kamyar
Qobadi, Ali
Aghazadeh, Elahe
Shirani, Kobra
Pourahmad, Jalal
author_facet Yousefsani, Bahareh Sadat
Mohajer, Kamyar
Qobadi, Ali
Aghazadeh, Elahe
Shirani, Kobra
Pourahmad, Jalal
author_sort Yousefsani, Bahareh Sadat
collection PubMed
description This study aimed to find out the mechanism of cytotoxic effects of galls of Quercus Brantii on A375 and SK-MEL-3 melanoma and AGO-1522 normal human fibroblast cell lines for the first time. Therefore, cell viability and cytotoxic activities were evaluated. Furthermore, ROS formation, lipid peroxidation, and release of cytochrome-c were also assessed. The results revealed that the extract of these galls at a concentration of 0.05 mg/ml significantly (P<0.001) increased cytotoxicity, ROS formation, TBARS formation, and cytochrome-c release in A375 and SK-MEL-3 melanoma cell lines compared to AGO-1522 normal human fibroblast. These results demonstrated that these galls can be considered a promising candidate which acts in synergy with anticancer agents used in the clinical treatment of human malignant melanoma.
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spelling pubmed-106764892023-03-01 The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines Yousefsani, Bahareh Sadat Mohajer, Kamyar Qobadi, Ali Aghazadeh, Elahe Shirani, Kobra Pourahmad, Jalal Asian Pac J Cancer Prev Research Article This study aimed to find out the mechanism of cytotoxic effects of galls of Quercus Brantii on A375 and SK-MEL-3 melanoma and AGO-1522 normal human fibroblast cell lines for the first time. Therefore, cell viability and cytotoxic activities were evaluated. Furthermore, ROS formation, lipid peroxidation, and release of cytochrome-c were also assessed. The results revealed that the extract of these galls at a concentration of 0.05 mg/ml significantly (P<0.001) increased cytotoxicity, ROS formation, TBARS formation, and cytochrome-c release in A375 and SK-MEL-3 melanoma cell lines compared to AGO-1522 normal human fibroblast. These results demonstrated that these galls can be considered a promising candidate which acts in synergy with anticancer agents used in the clinical treatment of human malignant melanoma. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10676489/ /pubmed/37505770 http://dx.doi.org/10.31557/APJCP.2023.24.7.2383 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Yousefsani, Bahareh Sadat
Mohajer, Kamyar
Qobadi, Ali
Aghazadeh, Elahe
Shirani, Kobra
Pourahmad, Jalal
The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines
title The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines
title_full The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines
title_fullStr The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines
title_full_unstemmed The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines
title_short The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines
title_sort selective cytotoxicity of quercus brantii lindl. galls on a375 and sk-mel-3 human malignant melanoma cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676489/
https://www.ncbi.nlm.nih.gov/pubmed/37505770
http://dx.doi.org/10.31557/APJCP.2023.24.7.2383
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