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Survival Analysis of Lung Cancer patients in Brunei Darussalam

BACKGROUND: Cancer has been the most common cause of deaths in Brunei Darussalam including lung cancer as one of the top killers. This study presents the survival analysis of primary lung cancer patients in Brunei Darussalam. METHODS: This is a retrospective cohort study of a 15-year period (2002-20...

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Autores principales: Kong, Jia En, Ong, Sok King, Leong, Elvynna, Naing, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676501/
https://www.ncbi.nlm.nih.gov/pubmed/37505771
http://dx.doi.org/10.31557/APJCP.2023.24.7.2389
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author Kong, Jia En
Ong, Sok King
Leong, Elvynna
Naing, Lin
author_facet Kong, Jia En
Ong, Sok King
Leong, Elvynna
Naing, Lin
author_sort Kong, Jia En
collection PubMed
description BACKGROUND: Cancer has been the most common cause of deaths in Brunei Darussalam including lung cancer as one of the top killers. This study presents the survival analysis of primary lung cancer patients in Brunei Darussalam. METHODS: This is a retrospective cohort study of a 15-year period (2002-2016) involving 797 primary lung cancer cases. De-identified data extracted from Brunei Darussalam Cancer Registry was analyzed using Kaplan-Meier method and log-rank test. Bonferroni corrections were performed. RESULTS: 6 months, 1-year, 3-year, 5-year survival rates of lung cancer patients were 62.2%, 51.0%, 38.0% and 34.7% respectively. The median survival time was 12.4 months (95% Cl: 9.2, 15.7). Patients diagnosed 2002-2006 had significant longer survival than patients diagnosed 2007-2011 (p=0.039) and those diagnosed 2011-2016 (p<0.001). Survival time of patients diagnosed 2007-2011 was significantly longer than patients diagnosed 2012-2016 (p=0.049). Patients with localised disease had significantly longer survival time than patients with regional involvement (p<0.001) and distal site involvement (p<0.001). Patients with distal disease had significantly poorer survival rate than patients with regional involvement (p<0.001). Patients aged 50 or above had significantly shorter survival time than patients diagnosed at age 40-49 (p=0.003). There was no significant difference between survival time of other demographic characteristics. CONCLUSIONS: The median survival time for lung cancer patients in this study was 12.4 months. Early diagnosis, early stage of cancer, and younger age were associated with longer survival time among lung cancer patients in Brunei Darussalam.
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spelling pubmed-106765012023-03-01 Survival Analysis of Lung Cancer patients in Brunei Darussalam Kong, Jia En Ong, Sok King Leong, Elvynna Naing, Lin Asian Pac J Cancer Prev Research Article BACKGROUND: Cancer has been the most common cause of deaths in Brunei Darussalam including lung cancer as one of the top killers. This study presents the survival analysis of primary lung cancer patients in Brunei Darussalam. METHODS: This is a retrospective cohort study of a 15-year period (2002-2016) involving 797 primary lung cancer cases. De-identified data extracted from Brunei Darussalam Cancer Registry was analyzed using Kaplan-Meier method and log-rank test. Bonferroni corrections were performed. RESULTS: 6 months, 1-year, 3-year, 5-year survival rates of lung cancer patients were 62.2%, 51.0%, 38.0% and 34.7% respectively. The median survival time was 12.4 months (95% Cl: 9.2, 15.7). Patients diagnosed 2002-2006 had significant longer survival than patients diagnosed 2007-2011 (p=0.039) and those diagnosed 2011-2016 (p<0.001). Survival time of patients diagnosed 2007-2011 was significantly longer than patients diagnosed 2012-2016 (p=0.049). Patients with localised disease had significantly longer survival time than patients with regional involvement (p<0.001) and distal site involvement (p<0.001). Patients with distal disease had significantly poorer survival rate than patients with regional involvement (p<0.001). Patients aged 50 or above had significantly shorter survival time than patients diagnosed at age 40-49 (p=0.003). There was no significant difference between survival time of other demographic characteristics. CONCLUSIONS: The median survival time for lung cancer patients in this study was 12.4 months. Early diagnosis, early stage of cancer, and younger age were associated with longer survival time among lung cancer patients in Brunei Darussalam. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10676501/ /pubmed/37505771 http://dx.doi.org/10.31557/APJCP.2023.24.7.2389 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Kong, Jia En
Ong, Sok King
Leong, Elvynna
Naing, Lin
Survival Analysis of Lung Cancer patients in Brunei Darussalam
title Survival Analysis of Lung Cancer patients in Brunei Darussalam
title_full Survival Analysis of Lung Cancer patients in Brunei Darussalam
title_fullStr Survival Analysis of Lung Cancer patients in Brunei Darussalam
title_full_unstemmed Survival Analysis of Lung Cancer patients in Brunei Darussalam
title_short Survival Analysis of Lung Cancer patients in Brunei Darussalam
title_sort survival analysis of lung cancer patients in brunei darussalam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676501/
https://www.ncbi.nlm.nih.gov/pubmed/37505771
http://dx.doi.org/10.31557/APJCP.2023.24.7.2389
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