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Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation

Obesity is associated with systemic inflammation, comorbidities like diabetes, cardiovascular disease and several cancers, cognitive decline and structural and functional brain changes. To treat, or potentially prevent these related comorbidities, individuals with obesity must achieve long-term sust...

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Autores principales: Custers, Emma, Franco, Ayla, Kiliaan, Amanda Johanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676679/
https://www.ncbi.nlm.nih.gov/pubmed/38026245
http://dx.doi.org/10.2147/JIR.S437156
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author Custers, Emma
Franco, Ayla
Kiliaan, Amanda Johanne
author_facet Custers, Emma
Franco, Ayla
Kiliaan, Amanda Johanne
author_sort Custers, Emma
collection PubMed
description Obesity is associated with systemic inflammation, comorbidities like diabetes, cardiovascular disease and several cancers, cognitive decline and structural and functional brain changes. To treat, or potentially prevent these related comorbidities, individuals with obesity must achieve long-term sustainable weight loss. Often life style interventions, such as dieting and increased physical activity are not successful in achieving long-term weight loss. Meanwhile bariatric surgery has emerged as a safe and effective procedure to treat obesity. Bariatric surgery causes changes in physiological processes, but it is still not fully understood which exact mechanisms are involved. The successful weight loss after bariatric surgery might depend on changes in various energy regulating hormones, such as ghrelin, glucagon-like peptide-1 and peptide YY. Moreover, changes in microbiota composition and white adipose tissue functionality might play a role. Here, we review the effect of obesity on neuroendocrine effects, microbiota composition and adipose tissue and how these may affect inflammation, brain structure and cognition. Finally, we will discuss how these obesity-related changes may improve after bariatric surgery.
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spelling pubmed-106766792023-11-22 Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation Custers, Emma Franco, Ayla Kiliaan, Amanda Johanne J Inflamm Res Review Obesity is associated with systemic inflammation, comorbidities like diabetes, cardiovascular disease and several cancers, cognitive decline and structural and functional brain changes. To treat, or potentially prevent these related comorbidities, individuals with obesity must achieve long-term sustainable weight loss. Often life style interventions, such as dieting and increased physical activity are not successful in achieving long-term weight loss. Meanwhile bariatric surgery has emerged as a safe and effective procedure to treat obesity. Bariatric surgery causes changes in physiological processes, but it is still not fully understood which exact mechanisms are involved. The successful weight loss after bariatric surgery might depend on changes in various energy regulating hormones, such as ghrelin, glucagon-like peptide-1 and peptide YY. Moreover, changes in microbiota composition and white adipose tissue functionality might play a role. Here, we review the effect of obesity on neuroendocrine effects, microbiota composition and adipose tissue and how these may affect inflammation, brain structure and cognition. Finally, we will discuss how these obesity-related changes may improve after bariatric surgery. Dove 2023-11-22 /pmc/articles/PMC10676679/ /pubmed/38026245 http://dx.doi.org/10.2147/JIR.S437156 Text en © 2023 Custers et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Custers, Emma
Franco, Ayla
Kiliaan, Amanda Johanne
Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation
title Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation
title_full Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation
title_fullStr Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation
title_full_unstemmed Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation
title_short Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation
title_sort bariatric surgery and gut-brain-axis driven alterations in cognition and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676679/
https://www.ncbi.nlm.nih.gov/pubmed/38026245
http://dx.doi.org/10.2147/JIR.S437156
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