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The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients
Objectives: Propolis has an anti-inflammatory effect induced by inhibiting cyclooxygenase, subsequent inhibition of prostaglandin and nitric oxide synthesis, reduction of inflammatory cytokines, and eventually immunosuppressive activity [1-3]. This study aims to evaluate the impact of propolis on cl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
HBKU Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676696/ https://www.ncbi.nlm.nih.gov/pubmed/38025331 http://dx.doi.org/10.5339/qmj.2023.sqac.21 |
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author | Jabbari-Azad, Farahzad Khoshkhui, Maryam Khalighi, Negar Mohammadi, Mojgan Emadzadeh, Maryam Aliabadi, Mehraneh Movahedi |
author_facet | Jabbari-Azad, Farahzad Khoshkhui, Maryam Khalighi, Negar Mohammadi, Mojgan Emadzadeh, Maryam Aliabadi, Mehraneh Movahedi |
author_sort | Jabbari-Azad, Farahzad |
collection | PubMed |
description | Objectives: Propolis has an anti-inflammatory effect induced by inhibiting cyclooxygenase, subsequent inhibition of prostaglandin and nitric oxide synthesis, reduction of inflammatory cytokines, and eventually immunosuppressive activity [1-3]. This study aims to evaluate the impact of propolis on clinical features and specific IgE levels against salsola in perennial allergic rhinitis patients. Methods: Thirty patients diagnosed with perennial allergic rhinitis with salsola-positive skin prick test were enrolled in this randomized controlled clinical trial and divided into two groups. The intervention group received the propolis (200 mg per day), and the control group received a placebo for four months, besides intranasal corticosteroids. At baseline and the end of the intervention, the level of Salsola-specific IgE was measured by the RAST method. To assess the propolis effect on the quality of life and disease severity, miniRQLQ and SNOT22 questionnaires were completed by patients before and after the intervention. Results: According to Table 1, Serum IgE level showed decreasing changes (-0.057) despite increasing changes in the control group (1.039). However, these differences were not statistically significant (P = 0.967). Based on the miniRQLQ questionnaire, quality of life improved in both groups without any significant difference (P = 0.930). According to the SNOT-22 questionnaire, both groups’ nasal and sinus problems decreased significantly. However, the intervention type did not affect this decrease and was observed over time in both groups (P> 0.05). Conclusion: Propolis supplementation did not significantly affect various laboratory parameters, clinical symptoms, and quality of life of patients with allergic rhinitis. |
format | Online Article Text |
id | pubmed-10676696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | HBKU Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106766962023-11-26 The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients Jabbari-Azad, Farahzad Khoshkhui, Maryam Khalighi, Negar Mohammadi, Mojgan Emadzadeh, Maryam Aliabadi, Mehraneh Movahedi Qatar Med J Second Qatar Allergy Conference Objectives: Propolis has an anti-inflammatory effect induced by inhibiting cyclooxygenase, subsequent inhibition of prostaglandin and nitric oxide synthesis, reduction of inflammatory cytokines, and eventually immunosuppressive activity [1-3]. This study aims to evaluate the impact of propolis on clinical features and specific IgE levels against salsola in perennial allergic rhinitis patients. Methods: Thirty patients diagnosed with perennial allergic rhinitis with salsola-positive skin prick test were enrolled in this randomized controlled clinical trial and divided into two groups. The intervention group received the propolis (200 mg per day), and the control group received a placebo for four months, besides intranasal corticosteroids. At baseline and the end of the intervention, the level of Salsola-specific IgE was measured by the RAST method. To assess the propolis effect on the quality of life and disease severity, miniRQLQ and SNOT22 questionnaires were completed by patients before and after the intervention. Results: According to Table 1, Serum IgE level showed decreasing changes (-0.057) despite increasing changes in the control group (1.039). However, these differences were not statistically significant (P = 0.967). Based on the miniRQLQ questionnaire, quality of life improved in both groups without any significant difference (P = 0.930). According to the SNOT-22 questionnaire, both groups’ nasal and sinus problems decreased significantly. However, the intervention type did not affect this decrease and was observed over time in both groups (P> 0.05). Conclusion: Propolis supplementation did not significantly affect various laboratory parameters, clinical symptoms, and quality of life of patients with allergic rhinitis. HBKU Press 2023-11-26 /pmc/articles/PMC10676696/ /pubmed/38025331 http://dx.doi.org/10.5339/qmj.2023.sqac.21 Text en © 2023 Jabbari-Azad, Khoshkhui, Khalighi, Mohammadi, Emadzadeh, Aliabadi, HBKU Press. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Second Qatar Allergy Conference Jabbari-Azad, Farahzad Khoshkhui, Maryam Khalighi, Negar Mohammadi, Mojgan Emadzadeh, Maryam Aliabadi, Mehraneh Movahedi The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients |
title | The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients |
title_full | The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients |
title_fullStr | The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients |
title_full_unstemmed | The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients |
title_short | The impact of propolis on clinical manifestations and specific IgE levels against salsola in perennial-allergic rhinitis patients |
title_sort | impact of propolis on clinical manifestations and specific ige levels against salsola in perennial-allergic rhinitis patients |
topic | Second Qatar Allergy Conference |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676696/ https://www.ncbi.nlm.nih.gov/pubmed/38025331 http://dx.doi.org/10.5339/qmj.2023.sqac.21 |
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