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Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study
PURPOSE: While prior research has highlighted a significant association between sleep characteristics and angina pectoris (AP) incidence, the link between sleep efficiency (SE) and angina remains unexplored. This study seeks to elucidate the relationship between AP and objectively quantified SE. PAT...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676697/ https://www.ncbi.nlm.nih.gov/pubmed/38021212 http://dx.doi.org/10.2147/NSS.S429231 |
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author | Liu, Jiali Zhu, Yuanqiang Chang, Yingjuan Xu, Ziliang Wang, Chen Zhang, Pengpeng Li, Shuangxin Yang, Wenxuan An, Rui Wen, Didi Xu, Jian Zheng, Minwen |
author_facet | Liu, Jiali Zhu, Yuanqiang Chang, Yingjuan Xu, Ziliang Wang, Chen Zhang, Pengpeng Li, Shuangxin Yang, Wenxuan An, Rui Wen, Didi Xu, Jian Zheng, Minwen |
author_sort | Liu, Jiali |
collection | PubMed |
description | PURPOSE: While prior research has highlighted a significant association between sleep characteristics and angina pectoris (AP) incidence, the link between sleep efficiency (SE) and angina remains unexplored. This study seeks to elucidate the relationship between AP and objectively quantified SE. PATIENTS AND METHODS: We examined a cohort of 2990 participants (1320 males and 1670 females; mean age 63.69 ± 13.2 years) from the Sleep Heart Health Study. The main exposure variable was SE, as determined by baseline home polysomnography, while the primary outcome was the first incidence of angina pectoris (AP) during the period between the baseline polysomnography and the end of follow-up. A multivariate Cox regression model was utilized, controlling for factors such as age, gender, BMI, smoking and alcohol consumption habits, diabetes, hypertension, sleep duration, triglycerides, cholesterol, high-density lipoprotein, apnea-hypopnea index, nocturnal oxygen saturation, to analyze the relationship between SE and AP. RESULTS: During an average follow-up of 11 years, 284 patients developed AP. The unadjusted Kaplan-Meier analysis identified the 2nd quartile of SE as having the lowest AP risk. The multivariate Cox proportional hazards model demonstrated a higher risk of AP in quartile 1 (HR, 1.679; 95% CI, 1.109–2.542; P <0.014) and quartile 3 (HR, 1.503; 95% CI, 1.037–2.179; P <0.031), compared to quartile 2 of SE. Upon stratified analysis, this relationship was particularly pronounced in hypertensive individuals. CONCLUSION: Our results highlight the critical role of optimal sleep efficiency in mitigating the risk of angina pectoris, especially among hypertensive individuals. |
format | Online Article Text |
id | pubmed-10676697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-106766972023-11-22 Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study Liu, Jiali Zhu, Yuanqiang Chang, Yingjuan Xu, Ziliang Wang, Chen Zhang, Pengpeng Li, Shuangxin Yang, Wenxuan An, Rui Wen, Didi Xu, Jian Zheng, Minwen Nat Sci Sleep Original Research PURPOSE: While prior research has highlighted a significant association between sleep characteristics and angina pectoris (AP) incidence, the link between sleep efficiency (SE) and angina remains unexplored. This study seeks to elucidate the relationship between AP and objectively quantified SE. PATIENTS AND METHODS: We examined a cohort of 2990 participants (1320 males and 1670 females; mean age 63.69 ± 13.2 years) from the Sleep Heart Health Study. The main exposure variable was SE, as determined by baseline home polysomnography, while the primary outcome was the first incidence of angina pectoris (AP) during the period between the baseline polysomnography and the end of follow-up. A multivariate Cox regression model was utilized, controlling for factors such as age, gender, BMI, smoking and alcohol consumption habits, diabetes, hypertension, sleep duration, triglycerides, cholesterol, high-density lipoprotein, apnea-hypopnea index, nocturnal oxygen saturation, to analyze the relationship between SE and AP. RESULTS: During an average follow-up of 11 years, 284 patients developed AP. The unadjusted Kaplan-Meier analysis identified the 2nd quartile of SE as having the lowest AP risk. The multivariate Cox proportional hazards model demonstrated a higher risk of AP in quartile 1 (HR, 1.679; 95% CI, 1.109–2.542; P <0.014) and quartile 3 (HR, 1.503; 95% CI, 1.037–2.179; P <0.031), compared to quartile 2 of SE. Upon stratified analysis, this relationship was particularly pronounced in hypertensive individuals. CONCLUSION: Our results highlight the critical role of optimal sleep efficiency in mitigating the risk of angina pectoris, especially among hypertensive individuals. Dove 2023-11-22 /pmc/articles/PMC10676697/ /pubmed/38021212 http://dx.doi.org/10.2147/NSS.S429231 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Liu, Jiali Zhu, Yuanqiang Chang, Yingjuan Xu, Ziliang Wang, Chen Zhang, Pengpeng Li, Shuangxin Yang, Wenxuan An, Rui Wen, Didi Xu, Jian Zheng, Minwen Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study |
title | Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study |
title_full | Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study |
title_fullStr | Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study |
title_full_unstemmed | Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study |
title_short | Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study |
title_sort | association of objective sleep characteristics and incident angina pectoris: a longitudinal analysis from the sleep heart health study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676697/ https://www.ncbi.nlm.nih.gov/pubmed/38021212 http://dx.doi.org/10.2147/NSS.S429231 |
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