262. Inhibiting macrophage Warburg effect blocks DNA hyper-methylation and restores immune function

BACKGROUND: Severe and chronic infections, such as sepsis and Tuberculosis (TB), lead to epigenetic-mediated immune suppression. Cancer studies have demonstrated that perturbations in TCA cycle intracellular metabolites trigger global changes in the epigenetic landscape, resulting in immune suppress...

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Detalles Bibliográficos
Autores principales: Abhimanyu, Abhimanyu, Ladki, Malik, Sheikh, Daanish, Nishiguchi, Tomoki, Carrero Longlax, Santiago, DiNardo, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677104/
http://dx.doi.org/10.1093/ofid/ofad500.334

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