740. Healthcare-associated invasive Staphylococcus aureus among adults with prior COVID-19-associated hospitalization, 2020

BACKGROUND: COVID-19 caused a large proportion of hospitalizations in 2020. We describe how COVID-19-associated hospitalizations affected the epidemiology of healthcare-associated (HA) invasive Staphylococcus aureus (iSA) infections. METHODS: The CDC Emerging Infections Program identified iSA cases and COVID-19-associated hospitalizations in adult surveillance area residents during March 1–December 31, 2020, from 9 counties in 6 states. iSA, HA (including hospital-onset [HO]) iSA, and iSA with prior COVID-19-associated hospitalization are defined in the Table. We used multivariable logistic regression to identify factors associated with COVID-19-associated hospitalization in persons with iSA infection and compared infection types and outcomes in iSA patients with and without prior COVID-19-associated hospitalization. [Figure: see text] RESULTS: Of 2,406 HA iSA cases reported, 146 (6.1%) had prior COVID-19-associated hospitalization. Most (58.9%) HA iSA cases with prior COVID-19-associated hospitalization were HO compared with 18.6% of other HA iSA cases (P< .01). The percentage of methicillin-resistant iSA cases was similar (HA iSA with prior COVID-19-associated hospitalization: 39.0% vs other HA iSA: 39.5%). In multivariable analysis, HA iSA cases with prior COVID-19-associated hospitalization more were often aged ≥65 years; of Hispanic ethnicity or Black race; had a central venous catheter, stay in a long-term care facility or long-term acute care hospital, and intensive care unit (ICU) admission before iSA culture; and less often had prior surgery and dialysis (Figure). The most common iSA-related diagnoses were bacteremia (HA iSA with prior COVID-19-associated hospitalization: 93.8% vs other HA iSA: 87.0%, P< .01) and pneumonia (32.9% vs 10.8%, P< .01). HA iSA cases with prior COVID-19-associated hospitalization more often were in the ICU after iSA culture (51.7% vs 26.6%, P< .01) and died (44.5% vs 13.8%, P< .01) vs other HA iSA cases. [Figure: see text] CONCLUSION: HA iSA cases with prior COVID-19-associated hospitalization were commonly HO, followed intensive care interventions, and had higher death rates. Further exploration of iSA risk factors during COVID-19-associated hospitalizations might identify ways to prevent iSA infections and ensuing severe outcomes. DISCLOSURES: Ghinwa Dumyati, MD, Pfizer: Grant/Research Support