2769. Treatment of Hypermutator Pseudomonas aeruginosa Induces Multidrug Resistance but Can Be Targeted by Combination Therapy

BACKGROUND: Up to 60% of Pseudomonas aeruginosa (Pa) strains isolated from human chronic lung infections lack an active DNA mismatch repair (MMR) system, resulting in a hypermutator phenotype. Hypermutator Pa isolates are associated with enhanced multidrug resistance and treatment failure, and treat...

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Detalles Bibliográficos
Autores principales: Hall, Kalen M, Wimley, William C, Bojanowski, Christine M, Pursell, Zachary F, Morici, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
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Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677162/
http://dx.doi.org/10.1093/ofid/ofad500.2380

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