1460. Assessing the impact of a surgical site infection prevention bundle on open reduction of fracture

BACKGROUND: In our hospital, risk of surgical site infection (SSI) after orthopaedic procedures varies approximately from 1% to 9% (Fig. 1). The objective of this study was to estimate the impact of a SSI prevention Bundle on the fracture-related infection (FRI) rates. [Figure: see text] METHODS: This is a single-center retrospective cohort study carried out between Jan/2021 and Dec/2022, which included patients undergoing any type of orthopaedic surgery for bone stabilization due to open fracture in a tertiary specialized public hospital in Belo Horizonte, a 3,000,000 inhabitants city from Brazil. Rates of SSI were assessed following implementing a Bundle that applied extended-spectrum antibiotics (cefuroxime with gentamicin) for prophylaxis towards patients at higher risk for postoperative SSI consisting of those with Charlson's comorbidity index score ≥ 5 and/or preoperative hospitalization longer than five days; intraoperative redosing of antibiotics for surgeries longer than 3 hours; carry out intraoperative rechecks, auditing surgical procedures using the infection prevention control team, and reinforcing good practices in the operating room (Fig. 2). The pre-intervention (Jan/2021 to Mar/2022) and post-intervention period (Apr/2022 to Dec/2022) were compared. Categorical variables were compared using the chi-square test, and continuous variables using the t-student test, considering a significance level of 5%. SSI risk and protective factors were identified by univariate, and multivariate analysis by logistic regression. [Figure: see text] RESULTS: 1,901 patients were included and analyzed: 1,037 and 864 were included in the “pre-intervention bundles” group and “post-intervention bundles” group, respectively. Rates of SSI in the “pre-intervention bundles” group and “post-intervention bundles” group were 6.9% (72/1037) and 2.8% (24/864), respectively (p<0.001). The overall risk for FRI following the intervention bundle dropped by 59% (Fig. 3). In a multivariate analysis, the relative risk of FRI after the Bundle implementation was 0.4 (Figs. 4, 5). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: The Bundle strategy implemented was effective in reducing the rates of FRI. These simple and affordable measures are suitable to be applied and replicated in low-income specialized public orthopaedic centers. DISCLOSURES: All Authors: No reported disclosures