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1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center

BACKGROUND: Non tuberculosis mycobacteria (NTM) are ubiquitous in the environment. The prevalence of NTM has increased worldwide, which is thought to be partly related to increased diagnostic testing but also possible aging populations, increased comorbid conditions and immunosuppression. NTM are co...

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Autores principales: Alsoubani, Majd, Park, Heidi, Vindenes, Tine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677287/
http://dx.doi.org/10.1093/ofid/ofad500.1717
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author Alsoubani, Majd
Park, Heidi
Vindenes, Tine
author_facet Alsoubani, Majd
Park, Heidi
Vindenes, Tine
author_sort Alsoubani, Majd
collection PubMed
description BACKGROUND: Non tuberculosis mycobacteria (NTM) are ubiquitous in the environment. The prevalence of NTM has increased worldwide, which is thought to be partly related to increased diagnostic testing but also possible aging populations, increased comorbid conditions and immunosuppression. NTM are considered rapidly emerging infections and often hard to treat. We aim to explore the true burden of NTM at Tufts Medical Center, a tertiary hospital serving a diverse patient population including a large immigrant Asian population METHODS: This was a retrospective case review study done at Tufts Medical Center, a tertiary academic hospital in Boston, MA. We identified adult patients with an ICD-10 diagnosis of NTM between January 2012 and March 2022. Clinical and microbiologic data was collected from the medical record. Patients without microbiology data in our institution were excluded. Chi-square and Fisher’s exact tests were used for categorical variables, student T-test was used for age. RESULTS: Out of 342 cases with an ICD-10 diagnosis of NTM, 197 patients met our inclusion criteria. In our sample, females represented 51.5% of cases. The majority of cases were white (48.2%) followed by Asian (42.6%). A third of patients with pulmonary NTM had a diagnosis of COPD and only 20% had documented past or current smoking history (Table 1). White patients were more likely to have extra pulmonary NTM compared to Asian patients (24 vs 5, p < 0.001). The most common site of NTM second to lung was skin and soft tissue (n=22, 10.9%). The most common NTM isolated from pulmonary site was Mycobacterium avium (n=85, 51.5%) while rapid growers [Mycobacterium chelonae (n=8, 25%), M.fortuitum (n=7,21.7%), and M. abscessus (n=7, 21.9%)] were the most common NTM isolated in extra pulmonary sites (Table 2). [Figure: see text] [Figure: see text] CONCLUSION: The epidemiological review of NTM at our urban institution has improved the understanding of the population we serve. Our data show high percentage of Asians with pulmonary NTM cultures and suggest higher predominance of extrapulmonary NTM in Caucasians compared to Asians. The majority of the extrapulmonary NTM were rapid growers. Larger epidemiologic studies and surveillance data are needed to better understand NTM in various environments and hosts. DISCLOSURES: All Authors: No reported disclosures
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spelling pubmed-106772872023-11-27 1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center Alsoubani, Majd Park, Heidi Vindenes, Tine Open Forum Infect Dis Abstract BACKGROUND: Non tuberculosis mycobacteria (NTM) are ubiquitous in the environment. The prevalence of NTM has increased worldwide, which is thought to be partly related to increased diagnostic testing but also possible aging populations, increased comorbid conditions and immunosuppression. NTM are considered rapidly emerging infections and often hard to treat. We aim to explore the true burden of NTM at Tufts Medical Center, a tertiary hospital serving a diverse patient population including a large immigrant Asian population METHODS: This was a retrospective case review study done at Tufts Medical Center, a tertiary academic hospital in Boston, MA. We identified adult patients with an ICD-10 diagnosis of NTM between January 2012 and March 2022. Clinical and microbiologic data was collected from the medical record. Patients without microbiology data in our institution were excluded. Chi-square and Fisher’s exact tests were used for categorical variables, student T-test was used for age. RESULTS: Out of 342 cases with an ICD-10 diagnosis of NTM, 197 patients met our inclusion criteria. In our sample, females represented 51.5% of cases. The majority of cases were white (48.2%) followed by Asian (42.6%). A third of patients with pulmonary NTM had a diagnosis of COPD and only 20% had documented past or current smoking history (Table 1). White patients were more likely to have extra pulmonary NTM compared to Asian patients (24 vs 5, p < 0.001). The most common site of NTM second to lung was skin and soft tissue (n=22, 10.9%). The most common NTM isolated from pulmonary site was Mycobacterium avium (n=85, 51.5%) while rapid growers [Mycobacterium chelonae (n=8, 25%), M.fortuitum (n=7,21.7%), and M. abscessus (n=7, 21.9%)] were the most common NTM isolated in extra pulmonary sites (Table 2). [Figure: see text] [Figure: see text] CONCLUSION: The epidemiological review of NTM at our urban institution has improved the understanding of the population we serve. Our data show high percentage of Asians with pulmonary NTM cultures and suggest higher predominance of extrapulmonary NTM in Caucasians compared to Asians. The majority of the extrapulmonary NTM were rapid growers. Larger epidemiologic studies and surveillance data are needed to better understand NTM in various environments and hosts. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2023-11-27 /pmc/articles/PMC10677287/ http://dx.doi.org/10.1093/ofid/ofad500.1717 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Alsoubani, Majd
Park, Heidi
Vindenes, Tine
1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center
title 1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center
title_full 1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center
title_fullStr 1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center
title_full_unstemmed 1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center
title_short 1889. The Epidemiology of Nontuberculosis Mycobacteria in a Single Urban Center
title_sort 1889. the epidemiology of nontuberculosis mycobacteria in a single urban center
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677287/
http://dx.doi.org/10.1093/ofid/ofad500.1717
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