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907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population

BACKGROUND: Respiratory syncytial virus the two modified prefusion (preF) protein antigens (DS-Cav1 and SC-TM) and the fusion (G) protein, (RSV), a major childhood respiratory pathogen, is gaining attention as an important pathogen in adults also, especially in older people and the immunocompromised...

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Autores principales: Nham, Eliel, Jang, A Yeung, Hyun, Hakjun, Yoon, Jin Gu, Noh, Ji Yun, Cheong, Hee Jin, Kim, Woo Joo, Ji, Hyun Jung, Seo, Ho Seong, Song, Joon Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677343/
http://dx.doi.org/10.1093/ofid/ofad500.952
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author Nham, Eliel
Jang, A Yeung
Hyun, Hakjun
Yoon, Jin Gu
Noh, Ji Yun
Cheong, Hee Jin
Kim, Woo Joo
Ji, Hyun Jung
Seo, Ho Seong
Song, Joon Young
author_facet Nham, Eliel
Jang, A Yeung
Hyun, Hakjun
Yoon, Jin Gu
Noh, Ji Yun
Cheong, Hee Jin
Kim, Woo Joo
Ji, Hyun Jung
Seo, Ho Seong
Song, Joon Young
author_sort Nham, Eliel
collection PubMed
description BACKGROUND: Respiratory syncytial virus the two modified prefusion (preF) protein antigens (DS-Cav1 and SC-TM) and the fusion (G) protein, (RSV), a major childhood respiratory pathogen, is gaining attention as an important pathogen in adults also, especially in older people and the immunocompromised. Studies on RSV seroprevalence in the adult population are limited, even though it is important to know the level of preexisting immunity to RSV now that approval of RSV vaccines seems imminent. Therefore, we aimed to analyze antibody levels against RSV across age groups. *This study was funded by the grant of the Ministry of Food and Drug Safety of South Korea (21172MFDS179). METHODS: A total of 150 serum samples were collected from 30 subjects of each age group (under 5 years, 5–18 years, 19–49 years, 50–64 years, and ≥65 years). Considering higher RSV disease burden in infants than older children, children under 5 were further divided into two age groups including 0–12 months and 13–59 months. Age-stratified seroprevalence was estimated using ELISA targeting the two modified prefusion (preF) protein antigens (DS-Cav1 and SC-TM) and the fusion (G) protein, the major immunogens and popular vaccine targets. Seropositivity was determined based on the concentration of medium-titer RSV antiserum manufactured by the United States National Institute of Health. RESULTS: Antibody titers against SC-TM were similar across age groups. Antibody titers against DS-Cav1 were higher than those against SC-TM in all age groups except children aged 0–12 months. There was no significant difference in antibody titers between children aged 0–12 months and 13–59 months. Only about one fifth participants aged under 5 and over 65 were seropositive to RSV preF. [Figure: see text] CONCLUSION: RSV seroprevalence was low overall. This study supports the importance of vaccination against RSV in infants and people over 65. DISCLOSURES: Hee Jin Cheong, M.D.,Ph.D., Sequiris: Advisor/Consultant
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spelling pubmed-106773432023-11-27 907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population Nham, Eliel Jang, A Yeung Hyun, Hakjun Yoon, Jin Gu Noh, Ji Yun Cheong, Hee Jin Kim, Woo Joo Ji, Hyun Jung Seo, Ho Seong Song, Joon Young Open Forum Infect Dis Abstract BACKGROUND: Respiratory syncytial virus the two modified prefusion (preF) protein antigens (DS-Cav1 and SC-TM) and the fusion (G) protein, (RSV), a major childhood respiratory pathogen, is gaining attention as an important pathogen in adults also, especially in older people and the immunocompromised. Studies on RSV seroprevalence in the adult population are limited, even though it is important to know the level of preexisting immunity to RSV now that approval of RSV vaccines seems imminent. Therefore, we aimed to analyze antibody levels against RSV across age groups. *This study was funded by the grant of the Ministry of Food and Drug Safety of South Korea (21172MFDS179). METHODS: A total of 150 serum samples were collected from 30 subjects of each age group (under 5 years, 5–18 years, 19–49 years, 50–64 years, and ≥65 years). Considering higher RSV disease burden in infants than older children, children under 5 were further divided into two age groups including 0–12 months and 13–59 months. Age-stratified seroprevalence was estimated using ELISA targeting the two modified prefusion (preF) protein antigens (DS-Cav1 and SC-TM) and the fusion (G) protein, the major immunogens and popular vaccine targets. Seropositivity was determined based on the concentration of medium-titer RSV antiserum manufactured by the United States National Institute of Health. RESULTS: Antibody titers against SC-TM were similar across age groups. Antibody titers against DS-Cav1 were higher than those against SC-TM in all age groups except children aged 0–12 months. There was no significant difference in antibody titers between children aged 0–12 months and 13–59 months. Only about one fifth participants aged under 5 and over 65 were seropositive to RSV preF. [Figure: see text] CONCLUSION: RSV seroprevalence was low overall. This study supports the importance of vaccination against RSV in infants and people over 65. DISCLOSURES: Hee Jin Cheong, M.D.,Ph.D., Sequiris: Advisor/Consultant Oxford University Press 2023-11-27 /pmc/articles/PMC10677343/ http://dx.doi.org/10.1093/ofid/ofad500.952 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Nham, Eliel
Jang, A Yeung
Hyun, Hakjun
Yoon, Jin Gu
Noh, Ji Yun
Cheong, Hee Jin
Kim, Woo Joo
Ji, Hyun Jung
Seo, Ho Seong
Song, Joon Young
907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population
title 907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population
title_full 907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population
title_fullStr 907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population
title_full_unstemmed 907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population
title_short 907. Age-stratified seroprevalence of respiratory syncytial virus in Korean population
title_sort 907. age-stratified seroprevalence of respiratory syncytial virus in korean population
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677343/
http://dx.doi.org/10.1093/ofid/ofad500.952
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