2547. Targeting penicillin-binding protein 2 (PBP2) to treat metallo-beta-lactamase (MBL)-producing Klebsiella pneumoniae: Mecillinam as an American Ninja Warrior

BACKGROUND: ‘Nightmare’ MBL gram-negatives resistant to nearly all antibiotics have emerged in the clinical setting and are a cause for concern. Here, we assessed the role of targeted PBP2 binding using mecillinam (MEC), which is currently available in other countries and has high affinity for PBP2,...

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Detalles Bibliográficos
Autores principales: Klem, Jack F, Candidate, Pharm D, Kaur, Jan Naseer, Smith, Nicholas M, Chen, Al, Holden, Patricia N, Bulitta, Jürgen B, Tsuji, Brian T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677522/
http://dx.doi.org/10.1093/ofid/ofad500.2164

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